Patents Assigned to Laboratories Serono SA
  • Use of prion conversion modulating agents
    Patent number: 7598046
    Abstract: The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in the pathogenesis of transmissible spongiform encephalopathics and other prion diseases.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: October 6, 2009
    Assignee: Laboratories Serono SA
    Inventors: Claudio Soto-Jara, Kinsey Maundrell
  • Pharmaceutically active sulfonyl hydrazide derivatives
    Patent number: 7432286
    Abstract: The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonyl hydrazide derivatives as well as to methods of their preparation.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: October 7, 2008
    Assignee: Laboratories Serono SA
    Inventors: Stephen Arkinstall, Serge Halazy, Dennis Church, Montserrat Camps, Thomas Rueckle, Jean-Pierre Gotteland, Marco Biamonte
  • Use of hCG in controlled ovarian hyperstimulation
    Patent number: 7405197
    Abstract: The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG, or a bio-analogue, is administered during the follicular phase.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: July 29, 2008
    Assignee: Laboratories Serono SA
    Inventor: Yves Menezo
  • Early diagnosis of conformational diseases
    Patent number: 7351526
    Abstract: A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: April 1, 2008
    Assignee: Laboratories Serono SA
    Inventors: Claudio Soto, Gabriella Saborio
  • Treatment of hepatitis C in the Asian population with subcutaneous interferon-beta
    Patent number: 7344709
    Abstract: The present invention relates to the use of recombinant IFN-beta for the production of a medicament for the treatment of HCV infection by subcutaneous administration to patients of Asian race, which failed to respond to a previous treatment with interferon-alpha, is herein reported. According to a preferred embodiment of the invention, this treatment can be better and further focused to those patients which after at least 4 weeks of initial treatment with IFN-beta show HCV RNA clearance.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 18, 2008
    Assignee: Laboratories Serono SA
    Inventors: Ian Parsons, Theodor Wee Tit Gin, Birgit Maschek
  • Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or CNS disorders
    Patent number: 7314878
    Abstract: The present invention is related to piperazine henzothiazole derivatives, notably for use in the treatment and/or prophylaxis of cerebral ischemic disorders or CNS disorders. The present invention is furthermore related to methods of their preparation.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: January 1, 2008
    Assignee: Laboratories Serono SA
    Inventors: Pascale Gaillard, Jean-Pierre Gotteland, Pierre-Alain Vitte