Abstract: The present invention relates to the effects of the epimeric mixture of cinchonains Ia and Ib on pathologies that involve alterations in the cardiovascular system, in combating, preventing and reverting ventricular fibrillation in human beings and animals, especially for combating spontaneous or electric-stimulus-induced ventricular fibrillation, to revert spontaneous or electric-stimulus-induced ventricular fibrillations, for preventing ventricular fibrillation, for the treatment of ventricular fibrillation of any etiology or for the treatment of post-fibrillation to maintain normal cardiac rhythm. The present invention further relates to methods for the synthesis of an epimeric mixture of the chemical substances cinchonain Ia and Ib. The present invention also relates to the use of these chemical substances in reverting/combating ventricular fibrillation and/or in protecting against ventricular fibrillation.
Abstract: The present invention relates to the use of a plant material of the species Trichilia sp., alone or in association with one or more of the following plants: Paullinia cupana (Sapindaceae), Croton moritibensis (Euphorbiaceae) and Zingiber officinale (Zingiberaceae) in the treatment, reversion, combat and/or prevention of ventricular fibrillation. A product particularly embraced by the present invention comprises the plant material of the species Trichilia sp., alone or in association with extracts from other plants. The invention also refers to the use of one or more fractions of plant extract from such plant material, particularly of Trichilia catigua A. Juss, and of one or more subfractions of said fractions in the treatment, combat, prevention and/or reversion of ventricular fibrillation.
Type:
Grant
Filed:
April 10, 2008
Date of Patent:
September 27, 2011
Assignee:
Laboratorio Catarinense S/A
Inventors:
Ney Osvaldo Silva Filho, Luc Edmond Leon Andre Raes, Carlos Eduardo De Carvalho, Irineu Tadeu Velasco, Vera Pontieri, Augusto Scalabrini Neto, Celia Ivete Fernandes
Abstract: The use of a plant material of the species Trichilia sp., alone or in association with one or more of the following plants: Paullinia cupana (Sapindaceae), Croton moritibensis (Euphorbiaceae) and Zingiber officinale (Zingiberaceae) in the treatment, reversion, combat and/or prevention of ventricular fibrillation. A product particularly embraced by the present invention comprises the plant material of the species Trichilia sp., alone or in association with extracts from other plants. The use of one or more fractions of plant extract from such plant material, particularly of Trichilia catigua A. Juss, and of one or more subfractions of said fractions in the treatment, combat, prevention and/or reversion of ventricular fibrillation.
Type:
Grant
Filed:
August 4, 2004
Date of Patent:
April 7, 2009
Assignee:
Laboratorio Catarinense S/A
Inventors:
Ney Osvaldo Silva Filho, Luc Edmond Leon Andre Raes, Carlos Eduardo De Carvalho, Irineu Tadeu Velasco, Vera Pontieri, Augusto Scalabrini Neto, Celia Ivete Fernandes
Abstract: The present invention relates to the use of a plant material of the species Trichilia sp., alone or in association with one or more of the following plants: Paullinia cupana (Sapindaceae), Croton moritibensis (Euphorbiaceae) and Zingiber officinale (Zingiberaceae) in the treatment, reversion, combat and/or prevention of ventricular fibrillation. A product particularly embraced by the present invention comprises the plant material of the species Trichilia sp., alone or in association with extracts from other plants. The invention also refers to the use of one or more fractions of plant extract from such plant material, particularly of Trichilia catigua A. Juss, and of one or more subfractions of said fractions in the treatment, combat, prevention and/or reversion of ventricular fibrillation.
Type:
Application
Filed:
August 4, 2004
Publication date:
December 21, 2006
Applicant:
Laboratorio Catarinense S/A
Inventors:
Ney Osvaldo Filho, Luc Edmund Andre Raes, Carlos Eduardo Carvalho, Irineu Velasco, Vera Pontieri, Augusto Neto, Celia Fernandes
Abstract: The present invention refers to a method for producing vasodilation or analgesia in a mammal, comprising the use of vegetal material derived from the bark of a Trichilia species.
Type:
Grant
Filed:
March 28, 2000
Date of Patent:
January 1, 2002
Assignee:
Laboratorio Catarinense S/A
Inventors:
Paulo Cezar Sander, Eduardo Augusto Moreira, Tadafissa Fujii, Zulma Raquel Vaz, Celso Shizuo Mizubuti, Roberto Mikio Kassuya, Andrea Bollmann, Aldo Piazera Junior, João Batista Calixto