Patents Assigned to Laboratorio Guidotti & C. S.p.A.
  • Nicotinic derivatives of glucosamine and related pharmaceutical compositions
    Patent number: 4358441
    Abstract: The nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate are described as having anti-lipolitic, hypocholesterolemizing and antiaterogenic activities, at an equal or higher level than those of nicotinic acid, without the objectionable side effects shown by the acid. To prepare the compounds of the invention, nicotinoyl chloride hydrochloride and glucosamine hydrochloride are reacted in an organic solvent at a temperature of between 40.degree. C. and 120.degree. C.
    Type: Grant
    Filed: May 19, 1981
    Date of Patent: November 9, 1982
    Assignee: Laboratorio Guidotti & C. S.p.A.
    Inventors: Walter Murmann, Osvaldo Ponchiroli
  • Process for the preparation of basic esters of substituted hydroxycyclohexanecarboxylic acids
    Patent number: 4336398
    Abstract: The yield of compounds having the general formula: ##EQU1## wherein R represents ##STR1## in the process comprising reacting a substituted hydroxycyclohexanecarboxylic acid with an aminoisopropyl chloride, is highly improved by heating the reaction mixture to 160.degree. to 240.degree. C. for at least 3 hours, and distilling under reduced pressure the resulting product. Thus the content of the undesired isomer is reduced to less than 1-1.5%.
    Type: Grant
    Filed: November 23, 1979
    Date of Patent: June 22, 1982
    Assignee: Laboratorio Guidotti & C. S.p.A.
    Inventor: Giorgio Sagramora