Abstract: Cerclage pessary containing progesterone homogeneously distributed in the pessary body providing a prolonged, sustained and continuous release for a period of at least 6 months, wherein the pessary consists of dimethylsiloxane elastomer with RTV (Room Temperature Vulcanization) mechanism, the progesterone amount is from 20% to 30% w/w, relative to pessary weight and the ratios of the polymers forming the matrix is from 6:1 to 14 1. The cerclage pessary is useful for the prevention of preterm birth. Progesterone diffuses through the polymer continuously, without altering the shape and integrity of the pessary, since the elastomer forming the polymeric matrix used herein is not biodegradable. This guarantees that the form of pessary remains intact until the end of treatment.

Abstract: The invention relates to a sustained-release vaginal ring which includes meloxicam and an agent for modulating the release of the active principle, such as polyvinylpyrrolidone K-30, which releases the active principle over at least 90 days and which can be used as a continuous-use contraceptive in women. The vaginal ring preferably includes 5 wt % to 30 wt % of meloxicam, relation to total weight of the formulation.

Abstract: The present invention features compositions and methods for the treatment of erectile dysfunction. The compositions include substantially pure polypeptides derived from ?-latrotoxin and can include other substances, such as pharmaceutically acceptable carriers or diluents, liposomes, hydrogels, and additional active ingredients for the treatment of erectile dysfunction. Also provided are methods, including methods for using the compositions for treatment of erectile dysfunction and in the preparation of medicaments.

Abstract: Cerclage pessary containing progesterone homogeneously distributed in the pessary body providing a prolonged, sustained and continuous release for a period of at least 6 months, wherein the pessary consists of dimethylsiloxane elastomer with RTV (Room Temperature Vulcanization) mechanism, the progesterone amount is from 20% to 30% w/w, relative to pessary weight and the ratios of the polymers forming the matrix is from 6:1 to 14 1. The cerclage pessary is useful for the prevention of preterm birth. Progesterone diffuses through the polymer continuously, without altering the shape and integrity of the pessary, since the elastomer forming the polymeric matrix used herein is not biodegradable.

Abstract: The present invention is directed to an active agent with contraceptive properties which corresponds to a peptide fragment of the Latrodectus mirabilisi's venom. The peptide generally includes the amino acid sequence of SEQ ID NO 2 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. Furthermore, a pharmaceutical contraceptive composition comprising the peptide fragment and one or more pharmaceutically acceptable vehicles is also described. The peptide fragment and pharmaceutical compositions are useful as a contraceptive and spermicide agent.

Abstract: The present invention is directed to an active agent with contraceptive properties. Said active agent corresponds to a molecular fraction of the venom from the spider Latrodectus mirabilis. The active agent is a peptide with a sequence according to SEQ ID NO 1 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. In a preferred embodiment, the active agent with contraceptive properties is a peptide with 10 to 30 amino acids, preferably 20 amino acids. Said embodiment is exemplified by the sequence identified as SEQ ID NO 2 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. Furthermore, a method to obtain the contraceptive peptide is disclosed, said method comprising cloning the nucleotide sequence in a microorganism.

Abstract: The invention relates to a novel pharmaceutical composition containing a complex of disulfiram (DSF) with a cyclodextrin (CD), to the method for obtaining same and to the use thereof in the treatment of alcohol and cocaine dependence.

Abstract: The present invention features compositions and methods for the treatment of erectile dysfunction. The compositions include substantially pure polypeptides derived from ?-latrotoxin and can include other substances, such as pharmaceutically acceptable carriers or diluents, liposomes, hydrogels, and additional active ingredients for the treatment of erectile dysfunction. Also provided are methods, including methods for using the compositions for treatment of erectile dysfunction and in the preparation of medicaments.

Abstract: The present invention consists in a process for obtaining polymers with antiviral activity which is characterized in that beginning with oligo or polysaccharides with a specific structure, polymers with a specific number of carbonyl groups are obtained by oxidation; in that the carbonyl groups of the oxidized oligo/polysaccharides are made to react with amino groups of molecules carrying amino and sulfonated groups, such as aliphatic aminosulfonates, in water or in mixtures of water with water-miscible solvents, under specific temperature, time, and pH conditions, giving rise to polymers carrying sulfonated groups, which are purified by conventional processes; in that the sulfonated polymers thus obtained have antiviral activity and either lack or present very low toxicity and anticoagulant activity, and are thus suitable for the production of pharmaceutical preparations suitable for use in topical or systemic antiviral therapy in humans or in animals. It is applicable in the pharmaceutical industry.

Abstract: A process for obtaining polymers with antiviral activity is disclosed. Molecules carrying carbonyl groups and hydroxyl groups in the .alpha. position relative to the carbonyl, and molecules carrying amino and sulfonated groups, react in water or in mixtures of water with water-miscible solvents. The reaction takes place under specific conditions of temperature, time and pH. The first reacting molecule may be a monosaccharide whereas the second reacting molecule may comprise aliphatic aminosulfates. Upon completion of the reaction the polymeric material is purified by conventional processes such that the polymeric material has a molecular weight between 1,500 and 100,000. The polymeric material has antiviral activity, either lacks or has very low toxicity and anticoagulant activity, and is thus suitable for pharmaceutical preparations for use in topical or systemic antiviral therapy in humans or animals.