Patents Assigned to Laboratorios Beta S.A.
  • Process for obtaining aspart insulin using a yeast strain
    Patent number: 8691530
    Abstract: The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: April 8, 2014
    Assignee: Laboratorios Beta S.A.
    Inventors: Nestor Annibali, Mercedes Goin, Graciela Trejo, Federico Carrizo, Diego Baruque, Analía Morales
  • PROCESS FOR OBTAINING ASPART INSULIN USING A PICHIA PASTORIS YEAST STRAIN
    Publication number: 20110117600
    Abstract: The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.
    Type: Application
    Filed: July 15, 2010
    Publication date: May 19, 2011
    Applicant: LABORATORIOS BETA S.A.
    Inventors: Nestor Annibali, Mercedes Goin, Graciela Trejo, Federico Carrizo, Diego Baruque, Analía Morales
  • Expression of a human insulin precursor in
    Patent number: 7091032
    Abstract: Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the constructions are capably of directing the expression and secretion of human insulin precursor of the formula B(1-30)-Y1-Y2-A(1-21), wherein Y1 is lysine or arginine; Y2 is lysine or arginine; B(1-30) is the B peptide of the human insulin; and B(1-21) is the A peptide of human insulin, and wherein the strain is yeast Pichia Pastoris. DNA constructions and method for obtaining the strain are also provided.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: August 15, 2006
    Assignee: Laboratorios Beta S.A.
    Inventor: Nestor Annibali
  • Method and composition for treating increased androgenic activity
    Patent number: 5506222
    Abstract: The present invention relates to spironolactone contain compositions for application to an area of human skin afflicted with acne, seborrheic condition or hirsutism. N,N-dialkyl lauramides are used as permeation enhancers.
    Type: Grant
    Filed: August 31, 1993
    Date of Patent: April 9, 1996
    Assignee: Laboratorios Beta S.A.
    Inventors: Francisco J. E. Stefano, Dario N. R. Carrara