Abstract: The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and/or treat acute and chronic pain developed as a consequence of surgery, especially superficial and/or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.
Type:
Grant
Filed:
February 4, 2011
Date of Patent:
December 19, 2017
Assignee:
Laboratorios De Dr. Esteve
Inventors:
José Miguel Vela Hernández, Daniel Zamanillo-Castanedo, Margarita Puig Riera de Conias
Abstract: The present invention relates to new substituted pyrazolo[1,5-a]pyridine having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
Type:
Grant
Filed:
February 21, 2013
Date of Patent:
November 8, 2016
Assignee:
LABORATORIOS DE DR. ESTEVE S.A.
Inventors:
José Luis Diaz Fernández, Ma Rosa Cuberes Altisent
Abstract: The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
Type:
Grant
Filed:
March 19, 2004
Date of Patent:
June 19, 2007
Assignee:
Laboratorios de Dr. Esteve S.A.
Inventors:
Rosa Cuberes Altisen, Jordi Frigola Constansa, Ines Alvarez Mathieu