Abstract: Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardization thereof.
Type:
Grant
Filed:
October 2, 2009
Date of Patent:
September 2, 2014
Assignee:
Laboratorios Farmacéutios Rovi, S.A.
Inventors:
Ivan Lopez-Belmonte Encina, Rafael Ojeda Martinez De Castilla