Abstract: The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycolin an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailability of the active ingredient, without toxic adverse effects.
Type:
Grant
Filed:
December 16, 2013
Date of Patent:
November 8, 2016
Assignee:
LABORATORIOS OJER PHARMA, S.L.
Inventors:
Carlos González Ojer, Raquel Maria Da Costa Martins, Josep M. Suñé Negre, Montserrat Miñarro Carmona, Josep Ramon Ticó Grau, Encarna García Montoya, Pilar Pérez Lozano, Manel Roig Carreras, Natalia Sánchez Porqueres
Abstract: Anhydrous topical gel composition of mupirocin or its salts comprising: a) a lipophilic base selected from the group consisting of petrolatum, medium-chain triglycerides, isopropyl myristate and mixtures thereof; b) a bioadhesive selected from the group comprising polyvinylpyrrolidone and polymethacrylates; and c) a solvent selected from the group comprising ethanol, propanol, and isopropanol; which is stable and shows an increased residence time of the active ingredient in the skin, resulting in an improved clinical effect in the treatment of bacterial skin infections while maintaining the safety profile of the commercial pharmaceutical product.
Type:
Grant
Filed:
October 19, 2011
Date of Patent:
December 8, 2015
Assignee:
LABORATORIOS OJER PHARMA, S.L.
Inventors:
Carlos González Ojer, Beatriz Goñi Allo, Fiona Pastor Fernández, Cayetana Yárnoz De Miguel
Abstract: The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycolin an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailability of the active ingredient, without toxic adverse effects.
Type:
Application
Filed:
December 16, 2013
Publication date:
December 3, 2015
Applicant:
LABORATORIOS OJER PHARMA, S.L.
Inventors:
Carlos GONZÁLEZ OJER, Raquel Maria DA COSTA MARTINS, Josep M. SUÑÉ NEGRE, Montserrat MIÑARRO CARMONA, Josep Ramon TICÓ GRAU, Encarna GARCÍA MONTOYA, Pilar PÉREZ LOZANO, Manel ROIG CARRERAS, Natalia SÁNCHEZ PORQUERES