Abstract: The disclosure features compositions and methods for treating a metabolic disorder, including diabetes, conditions associated with inhibition of insulin secretion, or for increasing longevity. In some embodiments, the methods comprise administering an anti-CGRP antagonist antibody.
Type:
Application
Filed:
October 11, 2016
Publication date:
February 9, 2017
Applicants:
Salk Institute for Biological Studies, The Regents of the University of California, Labrys Biologics, Inc.
Inventors:
Andrew Dillin, Celine Riera, Corey Goodman
Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
Type:
Grant
Filed:
April 14, 2014
Date of Patent:
August 25, 2015
Assignee:
Labrys Biologics, Inc.
Inventors:
Joerg Zeller, Kristian T. Poulsen, Yasmina Noubia Abdiche, Jaume Pons, Sierra Jones Collier, Arnon Rosenthal
Abstract: The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease and interstitial cystitis, by administering an anti-CGRP antagonist antibody.
Type:
Application
Filed:
October 18, 2013
Publication date:
October 23, 2014
Applicant:
Labrys Biologics, Inc.
Inventors:
Ariel Ates Pios, Kristian Todd Poulsen, David Louis Shelton, Joerg Zeller
Abstract: The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease and interstitial cystitis, by administering an anti-CGRP antagonist antibody.
Type:
Application
Filed:
June 4, 2014
Publication date:
October 16, 2014
Applicant:
Labrys Biologics, Inc.
Inventors:
Ariel Ates Pios, Kristian Todd Poulsen, David Louis Shelton, Joerg Zeller
Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
Type:
Grant
Filed:
November 21, 2013
Date of Patent:
May 27, 2014
Assignee:
Labrys Biologics, Inc.
Inventors:
Joerg Zeller, Kristian T. Poulsen, Yasmina Noubia Abdiche, Jaume Pons, Sierra Jones Collier, Arnon Rosenthal
Abstract: The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease and interstitial cystitis, by administering an anti-CGRP antagonist antibody.
Type:
Grant
Filed:
August 23, 2010
Date of Patent:
January 7, 2014
Assignee:
Labrys Biologics, Inc.
Inventors:
Ariel Ates Pios, Kristian Todd Poulsen, David Louis Shelton, Joerg Zeller
Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
Type:
Grant
Filed:
April 25, 2013
Date of Patent:
December 3, 2013
Assignee:
Labrys Biologics, Inc.
Inventors:
Joerg Zeller, Kristian T. Poulsen, Yasmina Noubia Abdiche, Jaume Pons, Sierra Jones Collier, Arnon Rosenthal
Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
Type:
Grant
Filed:
July 11, 2011
Date of Patent:
November 19, 2013
Assignee:
Labrys Biologics, Inc.
Inventors:
Joerg Zeller, Kristian T. Poulsen, Yasmina Noubia Abdiche, Jaume Pons, Sierra Lee Jones Collier, Arnon Rosenthal
Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.