Abstract: Compositions comprising vanoxerine (GBR 12909) and a P450 inhibitor, including compositions of vanoxerine and one or more P450 inhibitors, processes for their preparation thereof, and methods of using the same for treatment of cardiac arrhythmias.
Abstract: Methods of administration of vanoxerine wherein a patient, previously and successfully treated for cardiac arrhythmia with vanoxerine is prescribed a further dose for self-administration of a further dose of vanoxerine for treatment of a subsequent occurrence of cardiac arrhythmia.
Type:
Application
Filed:
April 25, 2014
Publication date:
February 11, 2016
Applicant:
Laguna Pharmaceuticals, Inc.
Inventors:
Arthur M. Brown, Rajesh K. Khosla, Howard C. Dittrich
Abstract: Novel piperazine compounds are disclosed. Also disclosed are pharmaceutical compositions containing these compounds and therapeutic methods of treating cardiac arrhythmias in mammals, particularly humans, including terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm using these compounds.