Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.
Type:
Grant
Filed:
October 8, 2024
Date of Patent:
April 14, 2026
Assignee:
Lahjavida, Inc.
Inventors:
Lyle D. Small, Ruizheng Wang, Shane M. Crippen
Abstract: A conjugate including a tumor-targeting NIR dye coupled to a therapeutic agent via a linker, whereby the dye functions to direct the conjugate and correspondingly, the therapeutic agent, to a target tumor cell population. Additionally, a method of killing tumor cells by directing a conjugate including a tumor-targeting NIR dye coupled to a therapeutic agent via a linker to a target tumor cell population.
Abstract: Provided herein are dye-drug conjugate (DDC) compounds comprising: a tumor-targeting near-infrared dye; a chemotherapeutic drug; and a cleavable linker, and methods of use thereof.
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