Patents Assigned to Lakewood-Amedex, Inc.
  • Antimicrobial compounds, compositions, and uses thereof
    Patent number: 11795192
    Abstract: Antimicrobial compounds and compositions of Formulas (V), (VI), (VII), (VIII), and (IX), and methods of use are disclosed.
    Type: Grant
    Filed: August 17, 2022
    Date of Patent: October 24, 2023
    Assignee: Lakewood Amedex, Inc.
    Inventors: Steven A. Kates, Randolph B. Sleet, Steven Parkinson
  • Antimicrobial compounds, compositions, and uses thereof
    Patent number: 11377468
    Abstract: A method of treating an infection of at least one of a wound or a ulcer in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: July 5, 2022
    Assignee: Lakewood Amedex, Inc.
    Inventors: Randolph B. Sleet, Steven A. Kates, Steven Parkinson
  • Methods and compositions for treating oral mucositis
    Patent number: 11123357
    Abstract: Methods and pharmaceutical compositions including Bisphosphocins for treating oral mucositis in a patient are disclosed.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: September 21, 2021
    Assignee: Lakewood Amedex, Inc.
    Inventors: Steven A. Kates, Steven Parkinson, Patrick C. O'Connor
  • Bisphosphocin gel formulations and uses thereof
    Patent number: 11096954
    Abstract: Gel formulations including a Bisphosphocin having antimicrobial activity are disclosed. Methods of using the gel formulations including a Bisphosphocin are further disclosed.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: August 24, 2021
    Assignee: Lakewood Amedex, Inc.
    Inventors: Steven A. Kates, Keith Arthur Johnson
  • Antimicrobial compounds, compositions, and uses thereof
    Patent number: 10981943
    Abstract: Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: April 20, 2021
    Assignee: Lakewood Amedex, Inc.
    Inventors: Randolph B. Sleet, Steven A. Kates, Steven Parkinson
  • Antimicrobial compounds, compositions, and uses thereof
    Patent number: 10752651
    Abstract: Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: August 25, 2020
    Assignee: Lakewood Amedex, Inc.
    Inventors: Randolph B. Sleet, Steven A. Kates, Steven Parkinson
  • Antimicrobial compounds, compositions, and uses thereof
    Patent number: 10711028
    Abstract: Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: July 14, 2020
    Assignee: Lakewood Amedex, Inc.
    Inventors: Randolph B. Sleet, Steven A. Kates, Steven Parkinson
  • Compositions and methods for the treatment of influenza infection
    Patent number: 10378014
    Abstract: The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment and prevention of influenza.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: August 13, 2019
    Assignee: Lakewood Amedex, Inc.
    Inventors: Roderic M.K. Dale, Lun-Quan Sun
  • Compositions and methods for the treatment of influenza infection
    Patent number: 9574243
    Abstract: The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment and prevention of influenza.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: February 21, 2017
    Assignee: Lakewood Amedex, Inc.
    Inventors: Roderic M. K. Dale, Lun-Quan Sun
  • Oligonucleotide—containing pharmacological compositions and their use
    Patent number: 9567584
    Abstract: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: February 14, 2017
    Assignee: Lakewood Amedex, Inc.
    Inventors: Roderic M.K. Dale, Amy Arrow, Teresa Thompson
  • Oligonucleotide-containing pharmacological compositions and their use
    Patent number: 8916529
    Abstract: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: December 23, 2014
    Assignee: Lakewood-Amedex, Inc.
    Inventors: Roderic M. K. Dale, Amy Arrow, Terry Thompson
  • Devices for improved wound management
    Patent number: 8435960
    Abstract: The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: May 7, 2013
    Assignee: Lakewood-Amedex, Inc.
    Inventors: Roderic M. K. Dale, Steven L. Gatton, Amy Arrow
  • Oligonucleotide-containing pharmacological compositions and their use
    Patent number: 8188259
    Abstract: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: May 29, 2012
    Assignee: Lakewood-Amedex, Inc.
    Inventors: Roderic M. K. Dale, Amy Arrow, Terry Thompson
  • Oligonucleotide-containing pharmacological compositions and their use
    Patent number: 8183361
    Abstract: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: May 22, 2012
    Assignee: Lakewood-Amedex, Inc.
    Inventors: Roderic M. K. Dale, Amy Arrow, Terry Thompson
  • Compositions and methods for the treatment of muscle wasting
    Patent number: 8097596
    Abstract: The invention provides compositions of oligonucleotides targeted at genes involved in muscle wasting and/or muscle growth. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment of muscle wasting conditions and/or the promotion of muscle growth.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: January 17, 2012
    Assignee: Lakewood-Amedex, Inc.
    Inventor: Roderic M. K. Dale
  • Antimicrobial and Antiviral Compounds and Methods for Their Use
    Publication number: 20110135713
    Abstract: The present invention provides protonated compounds having antiviral and antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi. The invention also provides antiviral compositions comprising compounds of the invention. Viruses that may be treated by compositions of the invention include, but are not limited to, HIV, HSV, CMV, HBV, HCV and influenza virus.
    Type: Application
    Filed: January 6, 2011
    Publication date: June 9, 2011
    Applicant: Lakewood-Amedex, Inc.
    Inventor: Roderic M.K. Dale
  • Antimicrobial and antiviral compounds and methods for their use
    Patent number: 7868162
    Abstract: The present invention provides protonated compounds having antiviral and antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi. The invention also provides antiviral compositions comprising compounds of the invention. Viruses that may be treated by compositions of the invention include, but are not limited to, HIV, HSV, CMV, HBV, HCV and influenza virus.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: January 11, 2011
    Assignee: Lakewood-Amedex, Inc.
    Inventor: Roderic M. K. Dale