Abstract: A medical boot includes a two piece boot body consisting of a lower flexible panel forming the sole portion of the boot body, and an annular flexible upper body joined to the peripheral edge of the lower panel so as to form a soft flexible protective wall around the toe and heel areas of the wearer's foot. Each panel includes a resilient foam core, an inner fabric covering on one face of the foam core, and an outer fabric covering on the other face of the foam core. The inner fabric covering has a relatively soft short nap surface having wicking properties for capturing perspiration that may accumulate on the wearer's foot. The outer fabric covering is a fibrous fastener material containing repeating contiguous miniature loops capable of interlocking connection with fastener patches carried by two strap formed integrally with the upper panel, such that the straps are enabled to hold the boot on the wearer's foot.