Abstract: Aspects and embodiments of the present invention relate to the treatment of neurological disorders such as for example, Alzheimer's disease and Parkinson's disease. Particularly, certain embodiments relate to GIP/GLP-1 co-agonist peptides for use in the treatment of these two neurological disorders. Also included in the present invention are inter alia pharmaceutical compositions comprising the GIP/GLP-1 co-agonist peptides, together with methods of treating such disorders as well as other subject matter.

Abstract: Aspects and embodiments of the present invention relate to the treatment of neurological disorders such as for example, Alzheimer's disease and Parkinson's disease. Particularly, certain embodiments relate to GIP/GLP-1 co-agonist peptides for use in the treatment of these two neurological disorders. Also included in the present invention are inter alia pharmaceutical compositions comprising the GIP/GLP-1 co-agonist peptides, together with methods of treating such disorders as well as other subject matter.

Abstract: A vertical-cavity surface-emitting laser (“VCSEL”) has at least a substrate, electrical contacts, a first mirror region, a second mirror region and an active region between the mirror regions; where the mirror regions comprise distributed Bragg reflectors formed of a plurality of layers; laser emission is from at least one gallium arsenide antimonide nanostructure in the active region; and each said nanostructure contains more antimony atoms than arsenic atoms.

Abstract: A memory cell for storing one or more bits of information has a control gate, a source terminal and a drain terminal. A semiconductor substrate is located between the source and drain terminals, and a floating gate is disposed between the control gate and the semiconductor substrate. The floating gate is electrically isolated from the control gate by a charge trapping barrier, and is electrically isolated from the semiconductor substrate by a charge blocking barrier. At least one of the charge trapping barrier and the charge blocking barrier contains a III-V semiconductor material. The charge trapping barrier is adapted to enable the selective passage of charge carriers between the control gate and the floating gate, in use, to modify the one or more bits of information stored by the memory cell.

Abstract: The present invention is a rectangular waveguide providing amplification of an electromagnetic wave via interaction with an electron beam in a linear interaction channel where the electron beam enters the waveguide at a first curved part of the waveguide, traverses the linear interaction channel and exits the waveguide at a second curved part of the waveguide.

Abstract: The present invention relates to a method of diagnosing, or providing a prognosis to, or for providing the likelihood of developing, malignant melanoma in a subject, the method comprising the steps of: (a) measuring two or more markers in blood perfusion dynamics at and/or around a skin lesion site; and (b) determining if the two or more markers is different to a normal value. The invention also relates to a device for diagnosing/providing a prognosis to/for malignant melanoma in a subject.

Abstract: Methods treat neurological disorders, for example neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke. Particularly although not exclusively, GIP/GLP-1 co-agonist peptide is used in the treatment of such neurological disorders. Pharmaceutical compositions include a GIP/GLP-1 co-agonist peptide for use in treatment of such disorders.

Abstract: The present invention is a rectangular waveguide providing amplification of an electromagnetic wave via interaction with an electron beam in a linear interaction channel where the electron beam enters the waveguide at a first curved part of the waveguide, traverses the linear interaction channel and exits the waveguide at a second curved part of the waveguide.

Abstract: Compositions useful for the prevention and/or treatment of Alzheimer's disease are disclosed. The composition comprises carrier particles each linked to a plurality of peptide constructs comprising a peptide binding sequence capable of binding to an amyloid protein and a transit amino acid sequence linked to said binding sequence. The binding sequence may be retroinverted D-peptide mimetic of an L-peptide binding sequence and the transit sequence may be a D-peptide mimetic of an L-peptide transit sequence (e.g. TAT) The preferred peptide construct comprises the sequence rGffvlkGrrrrqrrkkrGy. The preferred carrier particles are liposomes.

Abstract: A method of encoding data at a computer, the computer storing data associated with a plurality of dynamical subsystems, each dynamical subsystem having a plurality of associated state variables, the plurality of dynamical subsystems being coupled by a plurality of coupling functions. The method comprises receiving, at the computer, data to be encoded; inputting, at the computer, the data to be encoded into the plurality of dynamical subsystems as a plurality of parameters of the coupling functions; and outputting, from the computer, a plurality of state variables associated with the plurality of dynamical subsystems, the plurality of state variables comprising at least one of the plurality of state variables associated with each of the dynamical subsystems, the plurality of state variables providing an encoding of the received data.

Abstract: A method of processing text having an associated source type to generate data indicative of a property associated with said text, said text comprising a plurality of tokens.

Abstract: A method for forming a polished facet between an edge and a face of a sample, involves removing a first portion of the sample by directing an ion beam onto the edge adjacent the first portion along an ion beam axis to leave the polished facet. The ion beam axis lies on an ion beam plane oriented at a glancing incident angle, preferably from 1° to 30°, to a sample plane defined by and parallel to the first face. The ion beam is directed to flow from the edge towards the first face. Also disclosed is a sample preparation apparatus comprising a chamber adapted for evacuation with a sample holder adapted to hold a sample comprising a first face bounded by an edge, and an ion gun arranged to direct an ion beam along an ion beam axis towards the sample.

Abstract: A method of forming a metal layer on an electrically insulating substrate comprises depositing a photocatalyst layer onto the substrate and depositing a mask layer comprising voids on the substrate, such as a layer of latex microparticles with voids between them, to give an open pore structure to the mask. An electroless plating solution is then provided on the photocatalyst layer, and the photocatalyst layer and electroless plating solution are illuminated with actinic radiation whereby deposition of metal from the electroless plating solution to form a metal layer on the photocatalyst layer is initiated whereby the metal deposits in the voids of the mask layer. The mask layer is subsequently removed to leave a porous metal layer on the substrate. The method allows for deposition of porous metal films with controlled thickness and excellent adhesion onto electrically insulating substrates. The method is suitable for providing metal layers with controlled, regular porosity.

Abstract: Disclosed is a fluid sampling device comprising a plurality of inlet channels, each of which is arranged to receive an airflow from an associated direction, such that a sampling medium associated with a particular inlet channel is exposed to airflow from the associated direction.

Abstract: A method and apparatus for presenting an information signal such as an image signal or a sound signal using a plurality of signal sources. The plurality of signal sources are located within a predetermined space, and the method comprises receiving a respective positioning signals from each of said signal sources, generating location data indicative of locations of said plurality of signal sources, based upon said positioning signals, generating output data for each of said plurality of signal sources based upon said information signal and said location data, and transmitting said output data to said signal sources to present said information signal.

Abstract: A process for managing a screening interaction with a passenger, comprises a procedure for establishing an account from a passenger, and questions to establish the veracity of that account, such that more effective information can be gathered about the user's true intentions and identity. A computer apparatus intended to enable this process to be implemented is also described.

Abstract: A method for displaying a graphical user interface element to a user on a first display portion of a first display device and a second display portion of a second device. The method comprises displaying said graphical user interface element on said first display portion, receiving user input indicating movement of said graphical user interface element from said first display portion to said second display portion, said user input comprising selection of said graphical user interface element on said first display portion and movement of said graphical user interface element to said second display portion, and displaying said graphical user interface element on said second display portion; wherein said second device is an input device comprising a plurality of independently physically actuable members, each of said plurality of independently physically actuable members comprising a respective display surface, and said second display portion is formed by said plurality of display surfaces.

Abstract: A method of determining the state of a cable including at least one electrical conductor, uses a generated test signal and applies it to at least one conductor by a non-contact coupling transmitter. The resulting signal is propagated along the at least one conductor and a non-contact electrical coupling receiver picks up a reflected signal, and compares the reflected signal to expected state signal values for the cable to determine its current state.