Abstract: The present invention is generally directed towards compositions comprising ascorbic acid or ascorbate salt and an imaging agent, and related methods. In some embodiments, the imaging agent comprises pyridaben or a pyridaben analog attached to an imaging moiety.
Type:
Application
Filed:
July 21, 2023
Publication date:
March 28, 2024
Applicant:
Lantheus Medical Imaging, Inc.
Inventors:
James F. Castner, Dianne D. Zdankiewicz, James E. Anderson
Abstract: The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
Type:
Application
Filed:
July 14, 2023
Publication date:
March 28, 2024
Applicant:
Lantheus Medical Imaging, Inc.
Inventors:
Richard R. Cesati, Heike S. Radeke, Suresh K. Pandey, Ajay Purohit, Simon P. Robinson
Abstract: The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
Type:
Grant
Filed:
May 22, 2020
Date of Patent:
January 9, 2024
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
Abstract: The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
Type:
Grant
Filed:
October 25, 2019
Date of Patent:
September 5, 2023
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
Richard R. Cesati, Heike S. Radeke, Suresh K. Pandey, Ajay Purohit, Simon P. Robinson
Abstract: Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.
Abstract: The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
Type:
Application
Filed:
June 24, 2022
Publication date:
December 15, 2022
Applicant:
Lantheus Medical Imaging, Inc.
Inventors:
Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
Abstract: Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.
Type:
Application
Filed:
January 28, 2022
Publication date:
September 15, 2022
Applicant:
Lantheus Medical Imaging, Inc.
Inventors:
Ajay Purohit, Thomas D. Harris, Heike S. Radeke, Simon P. Robinson, Ming Yu, David S. Casebier, Michael T. Azure
Abstract: The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
Type:
Grant
Filed:
February 3, 2020
Date of Patent:
July 26, 2022
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
Abstract: A pierceable plug for closing off a piercing end of a needle is described herein. The plug has an end that is configured to be pierced by the needle to close off the piercing end of the needle. The plug may be radiation sterilizable and may be made of a material that includes an antimicrobial agent. The plug may be used to close off a needle end that is in fluid communication with a radioactive substance.
Type:
Application
Filed:
May 1, 2020
Publication date:
June 16, 2022
Applicant:
Lantheus Medical Imaging, Inc.
Inventors:
Joseph Haepers, Jack N. Wentz, JR., Virginia Ann Hankard, Khursida Shahidullah, Tricia D. Butland, Patricia A. Corosa, David P. Rice, Samantha Moran
Abstract: Techniques for monitoring a pharmaceutical manufacturing process and making determinations regarding the release of radiopharmaceuticals to health care providers. A data processing system collects data across multiple batches of radiopharmaceuticals, across multiple entities, and/or across multiple stages of the manufacturing process, processes the data, and provides feedback to entities involved in the manufacturing process. In scenarios where quality assurance tests are conducted, data is collected from radiopharmaceutical products before they are shipped, and the data is analyzed to provide the recipients with an indication of whether the radiopharmaceutical products satisfy quality assurance standards. Techniques for analyzing information about a batch manufacturing process and, when a problem occurred during a manufacture of a batch, determining whether to continue to manufacture a next batch in time for delivering and administering to a patient.