Abstract: There is disclosed a retractor system to facilitate surgical access to an intervertebral disc between an inferior vertebral body and a superior vertebral body. In an embodiment, the retractor system includes an elongate member having an anchor to attach to a pedicle of an inferior vertebral body with respect to an intervertebral disc. A retractor body has a collar to attach to the elongate member, slides coupled to the retractor body, and a pair of blades mounted to the slides. The blades have a proximal end and a distal end, a distance between the proximal end and the distal end of each one of the blades configured for displacing tissue for access to an intervertebral disc. An attachment portion is adjacent the proximal end of each one of the blades for attaching one of the slides thereto. Geometry of the blade end conforms to anatomy surrounding the pedicle.

Abstract: A dynamic spinal stabilization apparatus comprises a stabilization device such as a rod or a plate. Elongated bores, interfaces, or terminations packed with elastic material provides relative movement between the devices to allow spinal flexion and extension. Initially, relative movement may be constrained by a degradable materials, such as a resorbable material, to allow and screws to fuse to the associated bone.

Abstract: A bone plate assembly includes a plate, at least one bushing, and at least one bone screw. The bushing is positioned within a through hole of the plate. The bushing and screw are configured to engage each other to inhibit the screw from backing out. The screw includes a visual indicator surface that is visible to the operator during insertion of the screw through the bushing and plate. The bushing is configured to cover at least a portion of the visual indicator surface to show when the bushing and screw are properly engaged to inhibit backout of the screw.

Abstract: The present invention provides spinous process implant and associated methods. In one aspect of the invention the implant limits the maximum spacing between the spinous processes. In another aspect of the invention, a spacer has at least one transverse opening to facilitate tissue in-growth. In another aspect of the invention, an implant includes a spacer and separate extensions engageable with the spacer. In another aspect of the invention, instrumentation for inserting the implant is provided. In other aspects of the invention, methods for treating spine disease are provided.

Abstract: A bone plate assembly includes a plate, at least one bone screw, and at least one cap member. The screw extends into a through hole of the plate and a head of the screw seats in the through hole. The plate includes an undercut slot adjacent to the through hole. The cap includes at least one tab member that extends radially outward. The cap is mounted in the through hole with the tab member positioned in the undercut slot to inhibit the screw from backing out of the plate. In some arrangements, the tab member is rotatable within the undercut slot from an unlocked position to a locked position.

Abstract: Methods and compositions are described for preparing modified cells useful in various therapeutic applications.

Abstract: Surgical retractors, retractor insertion tools, and methods of use are disclosed. The surgical retractor includes a first protrusion end, a second insertion end opposite the first protrusion end, and an opening extending through the retractor body from a first end opening located at the first protrusion end of the retractor body to a second end opening located at the second insertion end of the retractor body.

Abstract: In one embodiment, a modular system for cervical fixation is disclosed. The system comprises a first plate operable to be attached to a first vertebra and a second plate operable to be attached to a second vertebra. A fixation means for connecting the first v-plate to the second v-plate is provided. The fixation means can be any one of a number of devices including a pair of beams that connect to the first and second plate, an attachment plate that attaches the first and second plates and an attachment plate that has an elastic middle portion.

Abstract: An expandable spinal fusion device is provided. The expandable device comprises a first part slidingly coupled to a second part. An removable expandable member extends between the first part and the second part and is coupled to a rotating operator such that rotating the operator causes the first part and the second part to move away from each other and distract vertebral bodies. A spacer or clip is used to lock the first part in relation to the second part to allow bone growth the fuse the vertebral bodies.

Abstract: The present invention provides a stabile construct to facilitate connecting a spinal fixation rod to a plurality of vertebral bodies. The construct or implant comprises a housing and an insert. The housing and insert are shaped to cooperatively engage the bone screw and rod to provide a stable construct that allows for polyaxial orientation between the bone screw and the remainder of the construct.

Abstract: Compositions and methods are provided for weight bearing surface, i.e., intervertebral disc (‘disc’), between spinous processes and articular cartilage, repair. Compositions include fibrosis inducing agents for facilitating fibrosis in or on the site in need of repair in order to form fibrotic connective tissue. In addition, methods are provided for distracting the appropriate disc space during treatment of a disc in need of repair, and in particular treatment of the disc in need of repair with a fibrosis inducing agent.

Abstract: A delivery mechanism comprising a dilator, catheter, lumen or the like is provided to allow a filler material to be injected to a gap in a partially fused intervertebral disc space to allow correction of the incomplete, partial, or deteriorated fusion.

Abstract: Compositions and methods are provided for stabilization and treatment of vertebrae, and in particular for stabilization and treatment of a vertebra having a fracture. Compositions are provided that stabilize and heal a fracture while facilitating healing and reducing the chance for re-injury to the vertebra or adjacent vertebra. Methods include elevation of the vertebra to facilitate healing under reduced pressure situations and include leverage points to elevate the fracture before or during composition insertion.

Abstract: The present invention provides an implant to be implanted between a superior vertebra and an inferior vertebra. The implant comprises a main body having a superior surface and an inferior surface with at least one linear surface protrusion residing on at least one of the superior surface or the inferior surface. The protrusion having a substantially flat bone engaging surface and a generally trapezoidal cross-section.

Abstract: The present invention provides a spinal implant for placement between adjacent processes of the human spine. In some embodiments the spinal implant includes a spacer and one or more retention members. In some embodiments, the retention members are fixed relative to the spacer and in other embodiments the retention members are deployable from a first or compact or stowed position to a second or expanded or deployed position. In some embodiments the spacer is expandable from a first size to a second size. In some embodiments the spacer has a tapered body.

Abstract: The present invention provides a bone fastener assembly useful in constructs for stabilizing bones of a patient. In one aspect of the invention, a bone fastener assembly includes a connecting member, a fastener seat, and a bone fastener. The fastener seat and fastener are receivable in the connecting member and the fastener seat is movable from a first position to a second position to retain the fastener in the connecting member. In another aspect of the invention, a bone fastener assembly includes a rod holder, a fastener seat mounted to the rod holder for rotation about the rod holder axis; and a bone, fastener. The bone fastener is generally “T”-shaped and engages the fastener seat in pivoting relationship such that the bone fastener is able to pivot to vary the angle between the bone fastener and the fastener seat.