Patents Assigned to Lark S.p.A.
  • Method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid
    Patent number: 4851563
    Abstract: A method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid, in which the ester is reacted with urea in the presence of a polar solvent and a strong acid.
    Type: Grant
    Filed: September 9, 1986
    Date of Patent: July 25, 1989
    Assignee: Lark S.p.A.
    Inventors: Goffredo A. Bolis, Giuseppe Cantarini, Marco Da Col
  • 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene derivatives
    Patent number: 4232013
    Abstract: New 16,17-pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene-derivatives have been prepared, useful as antiinflammatory agents on topical and/or systemic administration. An analogy process for the preparation of 16,17-pyrazolino-1,4-pregnadiene derivatives and the quite surprising conversion of the latter ones to 16,17-isopyrazolino-1,4-pregnadiene derivatives are also disclosed. The results of pharmacological comparative trails of some new products of the present invention v. fluocinolone acetonide are reported.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: November 4, 1980
    Assignee: Lark S.p.A.
    Inventors: Gaetano Palladino, Mario Micciarelli
  • 16-Alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-derivatives
    Patent number: 4031080
    Abstract: There is disclosed 16 alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-type compounds of the formula ##STR1## where R is hydrogen or acyl; X is hydrogen, bromine, or fluorine; Y is hydrogen or oxygen; and Z is hydrogen or .alpha.- or .beta.-oriented fluorine. The compounds are useful in treating rheumatoid arthritis and related inflammatory disorders as well as allergic diseases.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: June 21, 1977
    Assignee: Lark S.p.A.
    Inventor: Gaetano Palladino
  • Process for the preparation of 17-acyl esters of 17.alpha., 21-dihydroxysteroids of the pregnane series and novel products
    Patent number: 3998701
    Abstract: A process is disclosed for making 17-monoesters of 17 .alpha., 21-dihydroxy steroids by acylating a 17 .alpha., 21-dihydroxy steroid phosphate and then subjecting the intermediate 17-acyloxy-21-phosphate to dephosphorylation using an acid phosphatase to achieve enzymatic hydrolysis. Several new 17-monoesters having an anti-inflammatory property are also disclosed.
    Type: Grant
    Filed: December 3, 1974
    Date of Patent: December 21, 1976
    Assignee: Lark S.p.A.
    Inventors: Alberto Ercoli, Marco Da Col