Patents Assigned to Lars-Laboratoire d'Application et de Recherche Scientifique
  • Patent number: 7700147
    Abstract: Biomimetic artificial prostheses which are made from polyester, such as polyethylene terephthalate, and a method for the biomimetic functionalization of such prostheses. The method includes a step involving the grafting of biologically-active polymers or copolymers to the polyester surface of the prostheses, the grafting step consisting of the peroxidation of the surface by ozonation followed by a step including the radical polymerization of a solution of at least one monomer. The method also includes an optional step consisting in impregnating the prostheses with type I and/or II collagen and/or fibronectins. The prostheses thus obtained enable a normal and uniform regrowth of the fibroblasts, thereby significantly improving the biological integration of such polyester prostheses.
    Type: Grant
    Filed: January 19, 2004
    Date of Patent: April 20, 2010
    Assignee: LARS- Laboratoire d'Application et de Recherche Scientifique
    Inventors: Bernard Brulez, Jacques-Philippe Laboureau, Veronique Migonney, Mihaela Ciobanu, Graciela Pavon-Djavid, Alain Siove
  • Patent number: 7494506
    Abstract: Method for production of a prosthetic ligament (1), for the replacement of a natural joint ligament, having a global cylindrical form and including a medial intra-articular section (3) between two intra-osseous end parts (2). The method includes a step of the rolling or folding on itself of a web of synthetic polymer fibers, followed by a step of installation of a traction thread (5) to each of the ends (4) of the ligament (1), then a step of placing a tip (6) on the ends (5), characterized in that the placing of the tip (6) includes producing a radial ligature (60) of the ligament (1) provided with the traction threads (5), by of a ligature thread (7).
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: February 24, 2009
    Assignee: Lars-Laboratoire d'Application et de Recherche Scientifique
    Inventors: Bernard Brulez, Jacques-Philippe Laboureau
  • Publication number: 20070118217
    Abstract: Method for production of a prosthetic ligament (1), for the replacement of a natural joint ligament, having a global cylindrical form and including a medial intra-articular section (3) between two intra-osseous end parts (2). The method includes a step of the rolling or folding on itself of a web of synthetic polymer fibres, followed by a step of installation of a traction thread (5) to each of the ends (4) of the ligament (1), then a step of placing a tip (6) on the ends (5), characterized in that the placing of the tip (6) includes producing a radial ligature (60) of the ligament (1) provided with the traction threads (5), by of a ligature thread (7).
    Type: Application
    Filed: January 21, 2005
    Publication date: May 24, 2007
    Applicant: LARS-LABORATOIRE D' APPLICATION ET DE RECHERCHE SCIENTIFIQUE
    Inventors: Bernard Brulez, Jacques-Philippe Laboureau