Patents Assigned to Latvian Institute of Organic Synthesis
  • Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents
    Patent number: 10561681
    Abstract: The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: February 18, 2020
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Pavels Arsenjans, Jelena Vasiljeva, Ilona Domracheva, Irina Shestakova, Ivars Kalvins
  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures
    Patent number: 10105348
    Abstract: Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 23, 2018
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • Thieno [2,3-b] pyridines as multidrug resistance modulators
    Patent number: 9908893
    Abstract: The thieno[2,3-b]pyridines of general formula (I), wherein R1 is Me, C6H5, 3,4,5-(OMe)3C6H2, NH2; R2 is H, CN, COMe, COOC1-4alkyl, COOC2H4OMe, COOC2H4OPr(n); R3 is C6H4R6, 3,4-OCH2O—C6H3; 2-furanyl; R6 is 4-Cl, 4-NO2, 4-N(C1-4alkyl)2, 3-(C1-4alkyloxy), 4-(C1-4alkyloxy), 3,4-(C1-4alkyloxy)2, 3,4,5-(C1-4alkyloxy)3; R4 is NH2, NHCOMe; R5 is CN, COMe, COC6H4R7; CO-(2-naphthyl); R7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe)2, 3,4,5-(OMe)3 as multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: March 6, 2018
    Assignee: LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
    Inventors: Ivars Kalvins, Aivars Krauze, Signe Grinberga, Laura Krasnova, Elina Jaschenko, Ilona Domracheva, Ilze Adlere, Zigmars Andzans, Irina Shestakova, Gunars Duburs
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLING BODY MASS GAIN COMPRISING S-PHENOTROPIL
    Publication number: 20160250185
    Abstract: The invention relates to medicine, in particular S-Phenotropil ((S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide) containing pharmaceutical compositions and their use in control of body mass gain.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 1, 2016
    Applicant: Latvian Institute of Organic Synthesis
    Inventors: Ivars KALVINS, Liga ZVEJNIECE, Larisa VARACEVA, Aleksandrs CERNOBROVIJS, Antons LEBEDEVS, Maija DAMBROVA, Baiba SVALBE, Edgars LIEPINS
  • "Pharmaceutical composition for reducing the trimethylamine N-oxide level"
    Publication number: 20150313862
    Abstract: The invention discloses the use of pharmaceutical compositions containing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate and pharmaceutically acceptable salts thereof for trimethylamine N-oxide level decrease in a body.
    Type: Application
    Filed: October 24, 2013
    Publication date: November 5, 2015
    Applicant: Latvian Institute of Organic Synthesis
    Inventors: Ivars KALVINS, Maija DAMBROVA, Edgars LIEPINS, Elina MAKAROVA, Osvalds PUGOVICS, Solveiga GRINBERGA, Eduards SEVOSTJANOVS
  • Regeneration of 2,2?-cyclopropylidene-bis (oxazolines)
    Patent number: 8846944
    Abstract: The present invention provides a method for regeneration of chiral 2,2?-cyclopropylidene-bis(oxazolines), such as (3&R,3?aR,8aS,8?aS)-2,2?-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]-oxazole and (45,4?5,5R,5?R)-2,2?-cyclopropylidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2?-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2?-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2?-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: September 30, 2014
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Ivars Kalvinsh, Antons Lebedevs, Aleksandrs Chernobrovijs, Grigory Veinberg, Maksims Vorona, Agnija Ievina
  • Pharmaceutical composition on basis of reverse transcriptase inhibitor and meldonium
    Patent number: 7700576
    Abstract: Novel pharmaceutical compositions which contain one of the reverse transcriptase inhibitors, viz., Zidovudine, Lamivudine or Stavudine in clinically efficacious amount and Meldonium as well as pharmaceutically applicable excipients. It has been proved that inclusion of Meldonium in these pharmaceutical compositions essentially diminishes the cardio- and neuro-toxicity of the reverse transcriptase inhibitor.
    Type: Grant
    Filed: August 8, 2006
    Date of Patent: April 20, 2010
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Vija Klusha, Sergejs Isajevs, Jolanta Pupure, Juris Rumaks, Valentina Gordjushina, Immanuels Taivans, Ivars Kalvinsh