Abstract: Methods and devices for holding a composition are described. A first embodiment includes a support substrate that supports an array of film segments having an active agent-containing composition, the film segments being attached to the support substrate by a pattern of adhesive. Another embodiment involves a support substrate supporting film segments having the active agent-containing composition, the embodiment including a sealing material that is heat sealed to the support substrate to contain the film segments. A third embodiment involves a substrate holding the film segments in blister cavities; a sealing material is attached to the substrate to contain the segments in the blister cavities. Other embodiments refer to cold sealing support substrates and sealing material, methods of delivering a composition without separating a film segment from a substrate backing, and other alterations to the sealing material.

Abstract: Compositions and methods for delivering active agents to the skin of a subject, including a polymer, an active ingredient and a solvent are disclosed, the compositions being capable of delivery by rolling, spreading, aerosol or in droplets and of forming a film in contact with the skin.

Abstract: The preparation of extracts from olive fruits, olive tree leaves, olive oil as well as olive-press waste. The isolation of natural products from these extracts and the evaluation of the DNA protective antioxidant activity of the extracts and the purified compounds on intact cells.

Abstract: Topical application of a prostaglandin directly to the clitoris is effective for enhancing female sexual desire and responsiveness.

Abstract: The invention provides a prolamine-plant polar lipid association, wherein the prolamine and plant polar lipid components are present in such proportions so that stable films can be obtained with this association, which is preferably in the form of a hydro-alcoholic gel comprising: 20-40% w/w of prolamines, preferably gliadin; 0.1-5% w/w of ceramides, preferably wheat ceramides; hydro-ethanolic solution (35 to 80°) ad 100%. This association may be used for preparing films, patches, aerosols for use in the delivery of active substances such as therapeutic and cosmetic agents.

Abstract: A composition for use in a three layer transdermal delivery system is disclosed, the composition comprising an adhesive matrix having sufficient strength to maintain an association on the skin for at least 3 days. The adhesive matrix contains the flux enhancer linoleic acid, an anti-oxidant and an effective dose of one or more steroid hormones with female sex related activity.