Abstract: Methods and devices for holding a composition are described. A first embodiment includes a support substrate that supports an array of film segments having an active agent-containing composition, the film segments being attached to the support substrate by a pattern of adhesive. Another embodiment involves a support substrate supporting film segments having the active agent-containing composition, the embodiment including a sealing material that is heat sealed to the support substrate to contain the film segments. A third embodiment involves a substrate holding the film segments in blister cavities; a sealing material is attached to the substrate to contain the segments in the blister cavities. Other embodiments refer to cold sealing support substrates and sealing material, methods of delivering a composition without separating a film segment from a substrate backing, and other alterations to the sealing material.
Abstract: Compositions and methods for delivering active agents to the skin of a subject, including a polymer, an active ingredient and a solvent are disclosed, the compositions being capable of delivery by rolling, spreading, aerosol or in droplets and of forming a film in contact with the skin.
Type:
Grant
Filed:
April 7, 2003
Date of Patent:
August 1, 2006
Assignee:
Lavipharm S.A.
Inventors:
Spiros Fotinos, Ekaterini Tsardaka, George Koborozos
Abstract: The preparation of extracts from olive fruits, olive tree leaves, olive oil as well as olive-press waste. The isolation of natural products from these extracts and the evaluation of the DNA protective antioxidant activity of the extracts and the purified compounds on intact cells.
Abstract: A composition for use in a three layer transdermal delivery system is disclosed, the composition comprising an adhesive matrix having sufficient strength to maintain an association on the skin for at least 3 days. The adhesive matrix contains the flux enhancer linoleic acid, an anti-oxidant and an effective dose of one or more steroid hormones with female sex related activity.