Patents Assigned to Le Centre National de la Recherche
  • Patent number: 11903720
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: February 20, 2024
    Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Publication number: 20240043626
    Abstract: A method for the selective cleavage of a compound comprising an aromatic ring and a C—O—C linkage in the presence of a heterogeneous catalyst is provided. The heterogenous catalyst may be a supported noble metal catalyst doped with a halogen selected from the group consisting of chlorine and bromine. By using this method, it is possible to increase the selectivity and/or yield (preferably both) of aromatic compounds.
    Type: Application
    Filed: December 14, 2020
    Publication date: February 8, 2024
    Applicants: RHODIA OPERATIONS, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE, CENTRALE LILLE INSTITUT
    Inventors: Dan Wu, Vitaly Ordomsky, Andrei Khodakov, Stephane Streiff, Jianxia Zheng
  • Publication number: 20230050418
    Abstract: The present invention relates to the production of benzene derivatives from furfural and its derivatives. The present invention also relates to the preparation of novel intermediates derived from furfural and its derivatives. The present invention describes new routes for converting furfural and its derivatives into benzene derivatives including novel intermediates.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 16, 2023
    Applicants: RHODIA OPERATIONS, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS
    Inventors: Ivan Scodeller, Francois Jerome, Karine De Oliveira Vigier, Changru Ma, Raphael Johannes Wischert, Eric Muller
  • Patent number: 10879577
    Abstract: The present disclosure relates to a multilayer electromagnetic waveguide that includes a plurality of layers forming guide channels for an electromagnetic wave, and at least one transition device including at least one dielectric layer between two guide channels, referred to as coupled guide channels, extending as an extension. Each transition device includes at least one adaptation channel extending in a longitudinal direction, and each adaptation channel is defined by two electrically conductive walls. At least one wall extends along the dielectric spacer layer from one end of the coupled guide channel, over a length suitable for optimizing the transmission of an electromagnetic wave between the two coupled guide channels.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: December 29, 2020
    Assignees: CENTRE NATIONAL D'ETUDES SPATIALES CNES, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, L'UNIVERSITE DE RENNES 1
    Inventors: Nicolas Capet, Francesco Foglia Manzillo, Karim Tekkouk, Ronan Sauleau, Mauro Ettorre
  • Patent number: 10590060
    Abstract: A process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, said furfuryl alcohol being present in a quantity of at least 5% by weight, based on the total weight of the alcohols, and said catalyst comprising at least one triflate ligand and at least one metal selected from bismuth, gallium, aluminum, tin and iron.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: March 17, 2020
    Assignees: LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS
    Inventors: Alban Chappaz, Francois Jerome, Karine De Oliveira Vigier, Eric Muller, Jonathan Lai, Matthieu Corbet, Didier Morvan
  • Patent number: 10593817
    Abstract: The invention relates to a material comprising at least one compound having formula Bi1-xMxAg1-y-?M?yOS1-zM?z, the methods for producing said material and the use thereof as a semiconductor, such as for photovoltaic or photochemical use and, in particular, for supplying a photocurrent. The invention further relates to photovoltaic devices using said compounds.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: March 17, 2020
    Assignees: RHODIA OPERATIONS, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Thierry Le Mercier, Philippe Barboux, Tangui Le Bahers
  • Patent number: 10537276
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 21, 2020
    Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Patent number: 10429300
    Abstract: The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: October 1, 2019
    Assignees: The Johns Hopkins University, Le Centre National de la Recherche Scientifique, Aix-Marseilles University
    Inventors: Frank Bosmans, Pierre E. Bougis, Marie-France Eauclaire
  • Patent number: 10319565
    Abstract: A method for generating an ion flow asymmetry in a capacitively coupled radiofrequency plasma reactor comprising a step for energization of a first electrode by a radiofrequency voltage waveform. The standardized voltage waveform is an approximate waveform with a degree of approximation of a standardized sawtooth radiofrequency function having different rising and falling slopes. The degree of approximation of the approximate waveform and the pressure P of the gas are sufficiently high for causing the appearance of an asymmetry of the ion flows between the ion flow at the first electrode and the ion flow at a second electrode.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: June 11, 2019
    Assignee: LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Bastien Bruneau, Erik Johnson, Tatiana Novikova, Jean-Paul Booth
  • Patent number: 9962119
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and infersaccatic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: May 8, 2018
    Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Patent number: 9818393
    Abstract: An acoustically absorbent cell for an acoustic panel, comprising a layer with a porous matrix incorporating a plurality of acoustic resonators between a first face and a second face of the porous matrix is described. The resonators are ordered so as to form at least two substantially parallel rows each comprising at least two resonators and extending along the first and second faces.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: November 14, 2017
    Assignees: LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DU MAINE, SUPMECA
    Inventors: Clement Lagarrigue, Jean-Philippe Groby, Vincent Tournat, Olivier Dazel, Benoit Nennig
  • Patent number: 9810614
    Abstract: The method for evaluating the compactness of a layer of railroad ballast near a railroad tie includes at least one step of taking at least two measurements (11,11a,11b) of the penetration resistance (Qd) of the ballast (13) near one and the same railroad tie (10), and a step of calculating the mean value (Qdmean) of these measurements (11,11a,11b) of penetration resistance (Qd). Also provided are a device for implementing such a method and a method for predicting the settlement of the ballast of a railroad track including a step of evaluating the compactness of a ballast near a railroad tie.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 7, 2017
    Assignees: SNCF RESEAU, UNIVERSITE DE MONTPELLIER 2 SCIENCES ET TECHNIQUES, UNIVERSITE BLAISE PASCAL-CLERMONT II, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Gilles Saussine, Juan Carlos Quezada, Pierre Breul, Franck Radjai
  • Patent number: 9452432
    Abstract: The invention relates to a microfluidic circuit including at least one microchannel for the flow of a first fluid conveying drops or bubbles of at least one second fluid, characterized in that the height of the microchannel is sized so as to crush the drops or bubbles during the movement thereof, and in that the microchannel comprises at least one trough, extending at least partially in the direction of flow of the first fluid or an area for trapping drops or bubbles, said area or the trough having a height that is greater than the height of the microchannel, such that at least some of the drops or bubbles of the second fluid in the microchannel are drawn and guided into the trough or into the trapping area.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: September 27, 2016
    Assignees: ECOLE POLYTECHNIQUE, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Charles Baroud, Rémi Dangla, Francois Gallaire
  • Publication number: 20160158409
    Abstract: Calcium phosphate-based formulation for bone filling, comprising at least one adjuvant giving adhesion properties, wherein the at least one adjuvant is selected from the saccharide head surfactant group. The bone cement is characterized by adhesive properties particularly advantageous facilitating the setting of the cement and offering a better containment of the bone-cement or bone-cement-prosthesis interface.
    Type: Application
    Filed: January 8, 2016
    Publication date: June 9, 2016
    Applicants: TEKNIMED SAS, L' UNIVERSITE PAUL SABATIER (TOULOUSE III), LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alain LEONARD, Stéphane GONCALVES, Juliette FITREMANN, Ariane BERCIER
  • Publication number: 20150293000
    Abstract: The method for evaluating the compactness of a layer of railroad ballast near a railroad tie includes at least one step of taking at least two measurements (11,11a,11b) of the penetration resistance (Qd) of the ballast (13) near one and the same railroad tie (10), and a step of calculating the mean value (Qdmean) of these measurements (11,11a,11b) of penetration resistance. Also provided are a device for implementing such a method and a method for predicting the settlement of the ballast of a railroad track including a step of evaluating the compactness of a ballast near a railroad tie.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 15, 2015
    Applicants: SOCIETE NATIONALE DES CHEMINS DE FER FRANCAIS SNCF, UNIVERSITE DE MONTPELLIER 2 SCIENCES ET TECHNIQUES, UNIVERSITE BLAISE PASCAL- CLERMONT II, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Gilles Saussine, Juan Carlos Quezada, Pierre Breul, Franck Radjai
  • Patent number: 8928084
    Abstract: An ESD protection device, which is arranged to be active at a triggering voltage (Vt1) for providing ESD protection, comprises a first region of the first conductivity type formed in a semiconductor layer of the first conductivity type, the first region extending from a surface of the semiconductor layer and being coupled to a first current electrode (C) of the semiconductor device, a well region of a second conductivity type formed in the semiconductor layer extending from the surface of the semiconductor layer, and a second region of the second conductivity type formed in the well region, the second region being coupled to a second current electrode (B). The ESD protection device further comprises a floating region of the second conductivity type formed in the semiconductor layer between the first current electrode (C) and the well region and extending from the surface of the semiconductor layer a predetermined depth.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: January 6, 2015
    Assignees: Freescale Semiconductor, Inc., Le Centre National de la Recherché Scientifique (CNRS)
    Inventors: Philippe Renaud, Patrice Besse, Amaury Gendron, Nicolas Nolhier
  • Patent number: 8835622
    Abstract: The present invention relates to materials and methods for the expression of a gene of interest specifically in seeds of plants, even more specifically in oilseed plants. In particular, the invention provides an expression cassette for regulating seed-specific expression in plants.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: September 16, 2014
    Assignees: Bayer BioScience N.V., Le Centre National de la Recherche Scientifique
    Inventors: Franck Pinot, Daniele Werck, Jürgen Ehlting, Alexandre Olry, Peter Denolf, Katrien Van Audenhove, Lien Van de Putte, Esmeralda Posada
  • Patent number: 8805600
    Abstract: A flight control system includes at least one actuator for a mobile flight surface of an aircraft, and a flight control module in communication with the actuator. The module includes a first and a second computer. Each computer calculates a control command established according to at least one predetermined law for control of the flight surface. The first computer, known as validating computer, comprises logic means adapted for comparing its control command with that of the second computer, known as master computer, and for transmitting the result of the comparison to the actuator. The actuator comprises logic means adapted for deciding, on the basis of the result, to execute or not to execute the command of the master computer. An aircraft comprising such a system is also disclosed.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: August 12, 2014
    Assignees: Airbus Operations S.A.S., Le Centre National de la Recherche Scientifique (CNRS)
    Inventors: Manel Sghairi, Patrice Brot, Jean-Jacques Aubert, Agnan De Bonneval, Yves Crouzet
  • Patent number: 8759091
    Abstract: The present invention provides a reporter gene containing cell line with increased specificity and/or sensitivity for a particular extracellular signal of interest so that it can be used in a gene-reporter assay to accurately determine the presence and/or level of the extracellular signal of interest in the presence of other extracellular signals that are capable of activating the same signal transduction pathway as the extracellular signal of interest or that are capable of activating another signal transduction pathway capable of modulating the transcription of the reporter gene.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: June 24, 2014
    Assignees: Le Centre National de la Recherche Scientifique, Biomonitor Limited
    Inventors: Michael G. Tovey, Christophe Lallemand
  • Publication number: 20140135290
    Abstract: The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 15, 2014
    Applicants: ONCOSYNERGY, INC., LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: James HECK, Nicolas Winssinger, John C. Chabala, Sofia Barluenga, Ruihong Chen, Allan Rubenstein, Jin-Chen Yu