Patents Assigned to Le Centre National De Recherche Scientifique (CNRS)
  • Publication number: 20160319306
    Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.
    Type: Application
    Filed: June 24, 2016
    Publication date: November 3, 2016
    Applicants: Total Marketing Services, Le Centre National De Recherche Scientifique (CNRS), Université D'Aix Marseille, L'Institut National des Sciences Appliquées (INSA)
    Inventors: Laurence GIRBAL, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
  • Patent number: 9441213
    Abstract: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: September 13, 2016
    Assignees: Total Marketing Services, Le Centre National De Recherche Scientifique (CNRS), Université d'Aix-Marseille, L'Institut National des Sciences Appliquées (INSA)
    Inventors: Henri-Pierre Fierobe, Florence Mingardon, Angélique Chanal-Vial
  • Patent number: 9382306
    Abstract: The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal 1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 5, 2016
    Assignees: IPSEN PHARMA S.A.S., COMMISSARIAT A L'ENERGIE ATOMIQUE (CEA), LE CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Marie-Thérèse Paternostre, Jean-Christophe Cintrat, Céline Valery, Stéphane Roux, Bernard Rousseau, Maarten Ijsselstijn, Roland Cherif-Cheikh, Franck Artzner
  • Patent number: 8871479
    Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: October 28, 2014
    Assignees: Total Marketing Services, Le Centre National de Recherche Scientifiques (CNRS), L'Institut National des Sciences Appliquees (INSA), Universite d'Aix-Marseille
    Inventors: Henri-Pierre Fierobe, Angélique Chanal-Vial, Anne-Laure Molinier, Chantal Tardif, Luc Dedieu
  • Publication number: 20130115669
    Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.
    Type: Application
    Filed: January 9, 2013
    Publication date: May 9, 2013
    Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS, L'Institut National des Sciences Appliquées (INSA), L'Université de Provence, L'Université de la Mediterranée
    Inventors: Laurence GIRBAL, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
  • Publication number: 20120122176
    Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.
    Type: Application
    Filed: November 26, 2009
    Publication date: May 17, 2012
    Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS), L'Institut National des Sciences Appliquees (INSA), L'Universite de Provence, L'Universite de la Mediterranee
    Inventors: Henri-Pierre Fierobe, Angélique chanal-Vial, Anne-Laure Molinier, Chantal Tardif, Luc Dedieu
  • Publication number: 20110294184
    Abstract: The invention relates to applications of a cellulase of Pseudomonas sp. ND137, functional fragments and/or variants and engineered forms thereof, in the context of industrial bioprocessing, more particularly solvent production.
    Type: Application
    Filed: November 26, 2009
    Publication date: December 1, 2011
    Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS), L'Institut National des Sciences Appliquees (INSA), L'Universite de Provence, L'Universite de la Mediterranee
    Inventors: Henri-Pierre Fierobe, Angélique Chanal-Vial
  • Publication number: 20110236943
    Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.
    Type: Application
    Filed: December 2, 2009
    Publication date: September 29, 2011
    Applicants: Total S.A, Le Centre National de Recherche Scientifique (CNRS), L'Universite de la Mediterranee, L'Universite de Provence, L'Institut National des Sciences Appliquees (INSA)
    Inventors: Laurence Girbal, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
  • Publication number: 20110178013
    Abstract: The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.
    Type: Application
    Filed: September 29, 2009
    Publication date: July 21, 2011
    Applicants: Ipsen Pharma S.A.S., Commissariat a L'Energie Atomique Aux Energies Alternatives (C.E.A.), Le Centre National De Recherche Scientifique (CNRS)
    Inventors: Marie-Thérèse Paternostre, Jean-Christophe Cintrat, Céline Valery, Stéphane Roux, Bernard Rousseau, Maarten Ijsselstijn, Roland Cherif-Cheikh, Frank Artzner
  • Publication number: 20110129876
    Abstract: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.
    Type: Application
    Filed: July 30, 2009
    Publication date: June 2, 2011
    Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS), L'Universite de la Mediterranee, L'Universite de Provence, L'Instutut National des Sciences Appliquees (INSA)
    Inventors: Henri-Pierre Fierobe, Florence Mingardon, Angélique Chanal-Vial