Abstract: The present invention relates to a compound, and in particular to a bromophenol-pyrazoline compound and a synthesis method and use thereof. The bromophenol-pyrazoline compound is represented by a general structural formula below: The bromophenol-pyrazoline compound provided in the present invention has efficient inhibitory activity against the main protease Mpro, and interferes with the replication of coronavirus in cells, indicating that the compound has the effect of treating coronavirus pneumonia and thus has a broad prospect of application in the preparation of drugs for treating coronavirus pneumonia.
Type:
Grant
Filed:
July 14, 2021
Date of Patent:
November 21, 2023
Assignee:
Lead High Technology (QingDao) Co., Ltd
Inventors:
Dayong Shi, Xiangqian Li, Xin Wang, Jinbo Yang