Patent number: 9738600
Abstract: A11-14 are N or CR11-14, respectively, maximum two of the four positions A simultaneously N; R1 is C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, (di)C(1-6)alkylamino, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(1-3)alkyl)amino, all alkyl and cycloalkyl group carbon atoms optionally substituted with F and F or methyl, respectively; R2 and R3 independently H, F, methyl, ethyl, hydroxy, methoxy or R2 and R3 together is carbonyl, all present alkyl groups optionally substituted with F; R4 is H or C(1-6)alkyl; R5 is H, hydroxyethyl, methoxyethyl, C(1-6)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with F, Cl, C(1-2)alkyl, C(1-2)alkoxy or cyano; the sulfonyl group with R1 represented by one of R7-9; the remaining R6-14 are independently H, halogen, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl, all alkyl gr
Type:
Grant
Filed:
December 3, 2014
Date of Patent:
August 22, 2017
Assignee:
LEAD PHARMA CEL MODELS IP B.V.
Inventors:
Joseph Maria Gerardus Barbara Cals, Sander Bernardus Nabuurs
Publication number: 20160304448
Abstract: A11-14 are N or CR11-14, respectively, maximum two of the four positions A simultaneously N; R1 is C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, (di)C(1-6)alkylamino, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(1-3)alkyl)amino, all alkyl and cycloalkyl group carbon atoms optionally substituted with F and F or methyl, respectively; R2 and R3 independently H, F, methyl, ethyl, hydroxy, methoxy or R2 and R3 together is carbonyl, all present alkyl groups optionally substituted with F; R4 is H or C(1-6)alkyl; R5 is H, hydroxyethyl, methoxyethyl, C(1-6)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with F, Cl, C(1-2)alkyl, C(1-2)alkoxy or cyano; the sulfonyl group with R1 represented by one of R7-9; the remaining R6-14 are independently H, halogen, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl, all alkyl gr
Type:
Application
Filed:
December 3, 2014
Publication date:
October 20, 2016
Applicant:
LEAD PHARMA CEL MODELS IP B.V.
Inventors:
Joseph Maria Gerardus Barbara Cals, Sander Bernardus Nabuurs