Abstract: The present invention relates to the field of biomedicine and antibody engineering. Specifically, it relates to mono and multispecific multivalent single chain polypeptide molecules and derivatives thereof, preferably to multispecific single chain (tandem) trimerbodies with defined stoichiometry, to nucleic acid sequences and vectors encoding thereof, and host cells expressing the same. It further relates to methods of producing thereof, pharmaceutical compositions, kits, methods of treatment, use as diagnostics or imaging reagents and combination therapies using thereof.
Type:
Grant
Filed:
December 9, 2016
Date of Patent:
April 19, 2022
Assignee:
Leadartis, S.L.
Inventors:
Luis Álvarez Vallina, Laura Sanz Alcober
Abstract: The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.
Type:
Application
Filed:
October 17, 2011
Publication date:
May 21, 2015
Applicant:
LEADARTIS, S.L.
Inventors:
Luis Álvarez Vallina, Ángel Cuesta Martinez, Noelia Sainz Pastor, Laura Sanz Alcober
Abstract: The invention relates generally to a new trimerization domain useful for developing multifunctional and multivalent complexes. Particularly, the invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XV protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.
Type:
Application
Filed:
August 22, 2011
Publication date:
November 27, 2014
Applicant:
LEADARTIS, S.L.
Inventors:
Luis Álvarez Vallina, Ángel Cuesta-Martínez, Noelia Sainz Pastor, Laura Sanz Alcober