Patents Assigned to Leading BioSciences, Inc.
  • ADMINISTRATION OF SERINE PROTEASE INHIBITORS TO THE STOMACH
    Publication number: 20220370389
    Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.
    Type: Application
    Filed: August 4, 2022
    Publication date: November 24, 2022
    Applicants: LEADING BIOSCIENCES, INC., The Regents of the University of California
    Inventors: Geert W. Schmid-Schonbein, Yung-Tsai (Andrew) Lee, Jeng Wei
  • Administration of serine protease inhibitors to the stomach
    Patent number: 11439611
    Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: September 13, 2022
    Assignees: Leading BioSciences, Inc., The Regents of the University of California
    Inventors: Geert W. Schmid-Schonbein, Yung-Tsai (Andrew) Lee, Jeng Wei
  • COMPOSITIONS FOR THE TREATMENT OF AUTODIGESTION
    Publication number: 20220054439
    Abstract: Compositions for the treatment of shock, autodigestion, multi-organ failure, intestinal ischemia, or intestinal hypoperfusion are provided.
    Type: Application
    Filed: August 28, 2021
    Publication date: February 24, 2022
    Applicant: Leading Biosciences, Inc.
    Inventors: Thomas Hallam, Robin Jackman, John Rodenrys
  • Compositions and methods for treating and preventing adhesions and ileus
    Patent number: 11202768
    Abstract: Disclosed herein are pharmaceutical compositions useful for the treatment and prevention of adhesions and ileus.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: December 21, 2021
    Assignee: Leading Biosciences, Inc.
    Inventors: Thomas Hallam, John Rodenrys
  • Compositions for the treatment of autodigestion
    Patent number: 11123317
    Abstract: Compositions for the treatment of shock, autodigestion, multi-organ failure, intestinal ischemia, or intestinal hypoperfusion are provided.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: September 21, 2021
    Assignee: Leading BioSciences, Inc.
    Inventors: Thomas Hallam, Robin Jackman, John Rodenrys
  • Compositions for the treatment of autodigestion
    Patent number: 9775821
    Abstract: Compositions for the treatment of shock, autodigestion, multi-organ failure, intestinal ischemia, or intestinal hypoperfusion are provided.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: October 3, 2017
    Assignee: Leading BioSciences, Inc.
    Inventors: Thomas Hallam, Robin Jackman, John Rodenrys
  • Compositions for the treatment of autodigestion
    Patent number: 9314442
    Abstract: Compositions for the treatment of shock, autodigestion, multi-organ failure, intestinal ischemia, or intestinal hypoperfusion are provided.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: April 19, 2016
    Assignee: Leading BioSciences, Inc.
    Inventors: Thomas Hallam, Robin Jackman, John Rodenrys