Patents Assigned to Lee Laboratories, Inc.
  • Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
    Patent number: 5610023
    Abstract: A method is provided for the purification of Clostridium difficile Toxin A comprising reacting impure Toxin A with immobilized mono-specific polyclonal antibodies. The polyclonal antibodies are coupled to a hydrazide group containing matrix such as hydrazide activated agarose gel. The immobilized antibody is specific for Toxin A and will greatly purify Toxin A from a Toxin A containing solution. Antibodies raised to Toxin A purified according to the method are of higher activity than antibodies produced from prior art purified Toxin A.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: March 11, 1997
    Assignee: Lee Laboratories, Inc.
    Inventor: John W. Deutsch