Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.

Abstract: A compound capable of being used as a tumor inhibitor, a preparation method therefor, and application thereof. The compound has a structure represented by general formula I; a stereoisomer, an enantiomer, a raceme, a cis/trans isomer, a tautomer, and an isotopic variant of the compound are comprised; the compound can be used separately or in combination with other drugs for treating tumors or inflammatory diseases, or for treating other disorders or diseases mediated by the activity of MDM2 and/or MDM4, and shows prominent curative activity.

Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.

Abstract: A compound capable of being used as a tumor inhibitor, a preparation method therefor, and application thereof. The compound has a structure represented by general formula I; a stereoisomer, an enantiomer, a raceme, a cis/trans isomer, a tautomer, and an isotopic variant of the compound are comprised; the compound can be used separately or in combination with other drugs for treating tumors or inflammatory diseases, or for treating other disorders or diseases mediated by the activity of MDM2 and/or MDM4, and shows prominent curative activity.

Abstract: The invention provides a compound of Formula I, or its tautomer, mesomer, racemate, enantiomer, diastereoisomer or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compound of Formula I, its tautomer, mesomer, racemate, enantiomer, or diastereoisomer. Ring A, R1, R2, R3 and R4 are as defined in the specification. The invention further provides a method for preparing the compound of Formula I and their use in the manufacture of a medicament for the treatment of a cell proliferative disorder.

Abstract: Disclosed is a method for preparing an insulin glargine (GlyA21-ArgB31-AryB32-human insulin) crystal, comprising crystallizing the insulin glargine at pH 7.0-9.0 and in a crystallization solution containing a recombinant insulin glargine, an organic solvent of a 10-30% concentration by volume, a zinc compound, a phenol derivative, a salt and an organic acid.

Abstract: Disclosed is a method for preparing an insulin glargine (GlyA21-ArgB31-AryB32-human insulin) crystal, comprising crystallizing the insulin glargine at pH 7.0-9.0 and in a crystallization solution containing a recombinant insulin glargine, an organic solvent of a 10-30% concentration by volume, a zinc compound, a phenol derivative, a salt and an organic acid.

Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.

Abstract: A herbal composition containing Curcumae kwangsiensis (Ezhu), Herba Dendrobii nobile Lindl. (Shihu), Rhizoma Pinelliae preparatum (Fabanxia), Rhizoma Typhonii (Baifuzi) and other optional herbs. The composition can be processed into a form for administering to human patients with a cancerous disease for improving their health.

Abstract: A dental restoration system includes a plurality of proximal inlays of differing sizes for selection by a dentist to fit a prepared tooth cavity. In addition, a plurality of occlusal inlays is provided for covering the prepared tooth cavity and abutting the proximal inlays. In combination therewith, a curable restorative resin is provided for securing the proximal inlay in a blocking relationship with the end of a prepared tooth cavity and for securing the occlusal inlay to a bottom of the prepared tooth cavity and to the proximal inlay. The method of the present invention provides for forming a prepared tooth cavity and the utilization of curable restorative resins for providing modular-occlusal-distal (MOD) or modular-occlusal (MO) dental restorations using a modular preformed proximal and occlusal inlays to provide the usual appearance of an original natural tooth.

Abstract: The combination of a fingernail having adhered to the surface thereof and providing a smooth surface, a coating formed from a polymer of an acrylic monomer, a hydrocarbon solvent and a wax. The acrylic monomer can be acrylic or methacrylic. The solvent can be an alkane or alkene having 6 to 8 carbon atoms. The wax can be paraffin. Also included into the composition can be added an antioxidant and/or thickening agent.The novel method which comprises applying to a fingernail a liquid composition containing an acrylic monomer, a hydrocarbon solvent, and a wax, and allowing the composition to dry to form an adherent polymeric coating.The fingernail may be the natural fingernail alone, or together with an artificial fingernail extension.

Abstract: An artificial fingernail or tip formed of polymer plastic contains light diffusing means located only within the front distal portion, the light diffusing means including, a plurality of minute depressions within and throughout at least the upper surface of said polymer strip for providing a textured roughened surface to obtain a natural appearing contrast between the front distal portion and the back proximal portion of the nail. In an additional aspect, the appearance is further enhanced by inclusion of slight pigmentation of the plastic material.

Abstract: A highly tacky continuous, generally self-sustaining film of pressure sensitive adhesive (formed by combining two pre-formed pressure sensitive adhesive films) without any imbedded supporting film uniquely useful for the bonding of two variably curved surfaces in superposed relationship, especially where said two surfaces are a natural fingernail and a superimposed plastic artificial fingernail, the minimum thickness of said film being at least 8 mils, the maximum thickness being about 12 mils, and the minimum initial adhesion to low energy plastic surfaces of said adhesive being at least 9 as defined by 3M Guide at page 16.

Abstract: The novel system for the bonding of dental filling composites and orthodontic adhesives to tooth enamel wherein the enamel is treated with a 2.5%-15% aqueous solution of a strong mineral acid or organic acid. The enamel is rinsed with water and thoroughly dried. A curable hydrophilic monomer primer is placed upon the enamel, said enamel primer being selected from the group consisting of esters having the generic formula: ##STR1## wherein R is H or CH.sub.3 and n is 1-8; esters of the general formula: ##STR2## wherein R=H or CH.sub.3 and n is 2-8; the mono and dimethacrylates or acrylates of glycerol; andacrylic or methacrylic acid.A methacrylate or acrylate based orthodontic adhesive or dental composite is cured on the surface of the primed enamel to give a material strongly bonded to the enamel surface.

Abstract: A biologically compatible non-toxic composition which when mixed, is useful as an in situ curing endodonic filling material. The composition has two separately packaged components. One component is a paste which contains a low viscosity hydroxy terminated polydialkylsiloxane and a non-reactive silicone oil diluent having a viscosity of from about 20 to 20,000 centistrokes at 25.degree. C. and comprising a polydialkylsiloxane. The other component is a liquid which includes (i) the reaction product resulting from the refluxing at ambient pressure and a temperature of about 150.degree. to about 175.degree. C.

Abstract: Two component adhesive formulations are described that can be mixed to form compositions containing a curable liquid resin binder and filler. The liquid resin binder comprises from about 1% to about 60% of a lower alkoxy, lower alkyl methacrylate comprising methoxyethyl methacrylate, and from about 40% to about 99% of a polyunsaturated agent selected from the group consisting of aliphatic or aromatic diacrylates or dimethacrylates or mixtures thereof, the percentages being by weight based on the liquid resin binder. The filler forms up to 80% by weight of the adhesive composition and consists of finely divided inorganic filler, finely divided organic filler that may be soluble in the liquid resin binder, and mixtures thereof. The preferred compositions are useful as orthodontic adhesives and contain from about 10% to about 50% by weight of the liquid resin binder of methoxyethyl methacrylate.

Abstract: In an adhesive having two curable components designed to be coated in separate layers on one or more of two surfaces to be joined, and cured upon contact of the layers with each other, one component is a curable liquid primer having a viscosity of at least 800 cps but no more than about 50,000 cps at 23.degree. C., and the second component is a paste having a viscosity of at least 100,000 cps at 23.degree. C. The primer is formulated with a curable liquid monomer component of which at least 30% is an alkoxy alkyl methacrylate, any balance of curable monomer in the primer comprising monomer that is capable of copolymerizing with the first-named monomer and/or cross-linking with it. Also covers the method for joining together two irregular surfaces, utilizing such an adhesive formulation. Particularly intended for orthodontic adhesive applications.

Abstract: Improved composition for a fingernail coating having an acrylic binder, a peroxide catalyst, a tertiary amine accelerator, and a polymeric filler at least partially soluble in the coating. The acrylic binder contains a monoethylenically unsaturated monomer comprising at least a major proportion of methoxyethyl methacrylate. A polyfunctional monomer may be present that copolymerizes with the monoethylenically unsaturated monomer, for crosslinking and toughening.