Abstract: The invention relates to a method for producing rhizoxin and derivates of rhizoxin. The aim of the invention is to produce novel novel micro-organisms that synthesise rhizoxin or derivates of rhizoxin, and to provide a method for producing rhizoxin oder derivates thereof, without the disadvantages of prior art and in a simpler manner with a higher yield. To this end, bacterial symbionts of Rhizopus sp., in the form of Burkholderia Rhizoxina DSM 17360 or other Burkholderia Rhizoxina strains, are isolated, cultivated and used for the fermentive production of rhizoxin and/or derivates of rhizoxin in a submerged culture, and the rhizoxin and/or the derivates thereof are subsequently isolated from the culture supernatant.