Abstract: The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar? by photochemically reacting a precursor compound of formula (II): Ar—L—Ar? to form a biaryl compound of general formula: Ar—L—Ar?(II)?Ar—Ar? (I) wherein Ar and Ar?, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities.
Type:
Grant
Filed:
November 19, 2018
Date of Patent:
November 1, 2022
Assignee:
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut
Inventors:
Florian Kloss, Toni Neuwirth, Veit Haensch, Christian Hertweck
Abstract: This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
Type:
Application
Filed:
June 15, 2012
Publication date:
October 23, 2014
Applicant:
Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie E.V. Hans-Knoell-Institut (HKI)
Inventors:
Axel Brakhage, Hans-Martin Dahse, Christian Hertweck, Hans-Wilhelm Nuetzmann, Kirstin Scherlach
Abstract: The present invention relates to compounds of Formula (I) or salts thereof wherein R1, R2, R3, R4, R5, R6, and other variables enumerated under one or more of same are as defined herein. Compounds of Formula I have activity as antimicrobial agents. Also disclosed are pharmaceutical compositions and methods of treating and preventing microbial infections in mammals, for example, a tuberculosis or leprosy infection, which employ compounds of Formula (I) or salts thereof.
Type:
Grant
Filed:
June 25, 2008
Date of Patent:
May 14, 2013
Assignee:
Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knoell-Institut
Inventors:
Ute Moellmann, Vadim Makarov, Cole T. Stewart
Abstract: The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C56H75NO22. The invention also relates to a method for producing said antibiotic using the microorganism Streptomyces spec. DSM 13059, and to the use thereof as an antibacterial substance which is especially effective against infections with Gram positive bacteria, especially antibiotic-resistant germs.
Type:
Grant
Filed:
February 2, 2005
Date of Patent:
July 7, 2009
Assignee:
Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knoell-Institut
Inventors:
Ute Moellmann, Kerstin Herold, Martin Roth, Ingrid Groth, Friedrich Gollmick, Karin Brigitte Charlotte Graefe, legal representative, Andrea Graefe, legal representative, Susanna Graefe, legal representative, Udo Graefe
Abstract: The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C56H75NO22. The invention also relates to a method for producing said antibiotic using the microorganism Streptomyces spec. DSM 13059, and to the use thereof as an antibacterial substance which is especially effective against infections with Gram positive bacteria, especially antibiotic-resistant germs.