Abstract: In the automatic processing of tissue samples in a tissue processor, the tissue samples are placed in a retort of the tissue processor. The tissue samples are exposed to a fixation reagent (FIX) in the retort. Afterwards, the tissue samples are exposed to a dehydrating reagent (ALK). Thereafter, the retort is cleared with an intermedium (INT) for removing the dehydrating reagent (ALK). Finally, the tissue samples are treated with a carrier material (CAR). Between the clearing of the retort with the intermedium (INT) and the treatment of the tissue samples with the carrier material (CAR), the retort is cleared with a carrier material protecting reagent (CARPRO) in which the intermedium (INT) and the carrier material (CAR) can be mixed.

Abstract: A freezing microtome for the production of microscopable thin sections of tissue samples (60), comprising a cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) for freezing the tissue samples (60), a cutting device for cutting the frozen tissue samples (60) and a working chamber, in which the cutting device and at least a part of the cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) are arranged is described. The part of the cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) arranged in the working chamber contains a liquid coolant (70), in which the tissue samples (60) can be inserted for freezing.

Abstract: The present invention relates to a tissue embedding apparatus (1) for automatic embedding of at least one tissue sample (8). The tissue embedding apparatus (1) encompasses an input unit (2), an image acquisition unit (3), an embedding unit (4), at least one output unit (5, 6), and a control unit (7). A cassette (9) containing at least one tissue sample (8) is transferable to the input unit (2) of the tissue embedding apparatus (1). The tissue sample (8) is embeddable in an embedding medium by means of the embedding unit (4). The embedded tissue sample is outputtable with the at least one output unit (5). At least one image of the tissue sample (8) is acquirable with the image acquisition unit (3).

Abstract: A device for applying a histological section to a slide is described. The histological section is generated by a cutting action performed by a blade of a microtome. The device comprises a positioning device having a component that is rotatably mounted to a bearing and has a receptacle for receiving and holding the slide, wherein the positioning device is designed such that the slide received in the receptacle can be rotated about an axis of rotation of the rotatably mounted component.

Abstract: The present invention relates to a tissue infiltration device (1) for samples (34) contained in cassettes (5). The tissue infiltration device (1) comprises at least two liquid containers (7, 11a-11d, 13, 15) and a transport apparatus (6). A liquid (12, 14, 16) having a property that can be predetermined can be filled into a liquid container (7, 11a-11d, 13, 15). A plurality of cassettes (5) can be held by a transport device (4). Using the transport apparatus (6), a transport device (4) can be brought to a liquid container (7, 11a-11d, 13, 15) and/or moved away from a liquid container (7, 11a-11d, 13, 15). A sequence of operations (8) can be prescribed in which a transport device (4) runs through the liquid containers (7, 11a-11d, 13, 15) of the tissue infiltration device (1).

Abstract: The present invention relates to a device for braking or locking a shaft (6) of a microtome (1). The microtome (1) comprises the shaft (6), an actuating element (2), a movement mechanism (37) and a housing (38). With the movement mechanism (37) an object to be cut can be moved relative to a knife blade. The actuating element (2) can be manually actuated by an operator. As a result thereof, the shaft (6) can be rotated. Via the shaft (6), the movement mechanism (37) for performing the relative motion between the object and the knife blade can be driven. Further, the present invention relates to a method for operating a device for braking a shaft (6) of a microtome (1). So that the device can be used in a mechanically formed movement mechanism (37), the inventive device is characterized by an actuator and a braking unit (25). The braking unit (25) is connected in a rotatably fixed manner to the shaft (6).

Abstract: The present invention relates to a device for controlling a brake of a microtome. The microtome (1) has an actuating element (2), a movement mechanism (8) and a brake. With the aid of the movement mechanism (8), an object to be cut can be moved relative to a knife blade. The actuating element (2) can be manually actuated by an operator and, as a result thereof, the relative motion between the object and the knife blade can be performed with the movement mechanism (8). The relative motion can be locked with the aid of the brake. So that the relative motion between the object and the knife blade can be used in a mechanically designed movement mechanism (8) and/or the relative motion can be locked without an additional hand movement of the operator, the inventive device is characterized by at least one sensor unit (5, 13). The sensor unit (5, 13) is provided on the actuating element (2) or adjacent to the actuating element (2). With the aid of the sensor unit (5, 13) a contact by the operator can be determined.

Abstract: The invention relates to a device (10) for treating specimens, comprising a plurality of reagent containers (12) which are arranged in predetermined positions. Further, the device (10) comprises a transport mechanism (22a, 22b) for transporting at least one transport container (16a, 16b) which accommodates at least one carrier (20). On the carrier at least one specimen is placed. Further, the device (10) has a sensor (34) for determining the fill level (44) of the reagent containers (12) with reagents (42), the sensor (34) being arranged on the transport mechanism (22a, 22b). Further, the invention relates to a method for determining the fill level (44) of reagent containers (12) with reagents (42).

Abstract: A method for the automatic and contact-free relative approach between a specimen (6) and a knife (7) of a microtome (1), wherein the knife (7) has a knife blade and is fixed in a knife holder (3), and the specimen (6) is fixed in a specimen holder (5) which is mounted on a drive unit (4) for generating a relative motion between the knife (7) and the specimen (6), wherein between the knife (7) and the specimen (6) a light barrier with transmitter and receiver is arranged, and a light beam coming from the transmitter runs parallel to the knife blade, characterized by a drive unit (4) which drives the specimen holder (5) relative to the knife holder (3) or the knife holder (3) relative to the specimen holder (5) for performing a coarse and section thickness feed movement in a first spatial direction (X) and for performing a cutting movement in a second spatial direction (Y) perpendicular to the first spatial direction (X), wherein the light barrier is formed as a light band (8) comprising a plurality of individu

Abstract: A tissue processor (1) is described, having a retort (2) for processing histological samples with different reagents, having multiple reagent reservoir vessels (3), and having a conduit system and a control device (5) for delivering reagents out of the reagent reservoir vessels (3) into the retort (2). A suction conduit (11) projects into each reagent reservoir vessel (3) through the vessel opening (7) for reagent withdrawal. A closure system (12) having an externally tapered and internally hollow closure plug (13) is provided for closing off the vessel opening (7). The suction conduit (11) is guided through a cavity (14) of the closure plug (13) for reagent withdrawal.

Abstract: A method and a device for producing thin sections of a sample by means of a microtome is described, in which a camera acquires at least one image of a surface generated by sectioning of the sample. With the aid of an evaluation device, the image of the surface is evaluated in terms of predefined characteristic values of a section quality. As a function of the characteristic values that are identified, a decision is then made as to whether the section of the sample is accepted or not.

Abstract: An apparatus for preferably automatic handling and/or processing of objects (1), in particular in the field of medical technology, having at least one processing station (3) and one object carrier (2) for bringing the object (1) to the processing station (3), optionally through the processing station (3), and away from the processing station (3), is characterized in that the object carrier (2) has a code; that data concerning the object (1) and/or the handling or processing of the object (1) can be assigned to the code; and that the data can be read or retrieved by way of the code.

Abstract: A method for operating a tissue processor and a respective tissue processor for performing this method are described for the processing tissue samples. The tissue processor comprises at least one retort for receiving the tissue samples and at least one container for receiving a process medium. The process medium is transferred at least one of from the container into the retort and from the retort into the container. A value is automatically measured in the course of transferring the process medium, the value representing a characteristic property of the process medium. The process medium is identified based on the value.

Abstract: An apparatus and a method for processing tissue samples are described. The apparatus comprises: at least one retort for accommodating tissue samples; at least one container for storing alcohol or xylene; a valve adapted to connect the at least one retort with the at least one container depending on an operating position of the valve; and at least a first sensor that is arranged in flow direction between the container and the retort for measuring a value of a parameter that represents a purity level of the alcohol or xylene; wherein the first sensor and the valve are configured to replace the alcohol or xylene depending on the value of the parameter that represents the purity level. The method comprises for the alcohol or xylene conducting between the container and the retort; automatically measuring the purity level and replacing depending on the purity level.

Abstract: A method and apparatus for operating a microtome are described. According to the method, a specific type of a sample to be sectioned is detected, at least one stored sectioning parameter value is determined as a function of the specific type of the sample that was detected, said value being allocated to the specific type of the sample and defines a specific setting of the microtome, and the setting the microtome as defined by the determined sectioning parameter value is performed automatically.

Abstract: A method and an apparatus for the treatment of cytological and histological specimens are described. A treatment program comprising multiple treatment parameters is predetermined. The specimens are introduced in accordance with the predetermined treatment program sequentially into a plurality of treatment stations by means of a transport device. At least one of the process data time and number of specimens subject to simultaneous treatment in one particular treatment station and number of the treatment stations during execution of the treatment program are determined. These process data are evaluated for optimizing the treatment program as to at least one of processing time, number of treatment stations and sequence of treatment stations.

Abstract: A method for determining reagent quality in a device having multiple treatment stations for the treatment of at least one of cytological and histological prepared specimens and an apparatus for performing this method are described. The method comprises providing a carrier element that comprises at least one test material; transferring and treating the carrier element having test material according to a predefined sequence in a plurality of the treatment stations together with the specimens; and evaluating the test material by means of an evaluation device after treatment in the last treatment station in sequence. The described method and apparatus achieve that reagent quality can be determined automatically and the reagents can be replaced at an optimum point in time.

Abstract: An apparatus for storing at least one specimen slide and at least one cassette comprising a sample that is embedded in a sample block and that is to be processed, a microtome comprising this apparatus, and a method for handling multiple cassettes and multiple specimen slides are described. A cassette magazine receives at least one cassette having at least one sample block. A slide magazine receives at least one specimen slide. At least one connecting element for connecting the cassette magazine and the slide magazine mechanically with each other is provided. This allows handling at least one cassette and at least one specimen slide together in a simple and efficient manner.

Abstract: An apparatus and method for tagging a specimen slide are described. The apparatus comprises a receiving region for receiving at least one cassette magazine, a reading unit for reading the machine-readable coded information of a cassette identifier of a cassette, and a tagging unit for generating a machine-readable coded information for tagging the specimen slide with a specimen slide identifier that depends on the cassette identifier. Data are transferred from the microtome to the apparatus via the data transfer path as soon as the cassette is inserted into the microtome, and only then can the machine-readable coded information for tagging the specimen slide be applied onto the specimen slide by the tagging unit.

Abstract: An apparatus is described for treating prepared specimens. The apparatus comprises at least two container rows arranged in parallel to each other, each comprising a plurality of reagent containers and a transport mechanism for transporting at least one transport container that receives at least one carrier holding at least one prepared specimen. The transport mechanism is movable along an X and Z axis. A rotation unit is provided comprising holding arms and at least one holding element. The container rows are received rotatably at the ends of the holding arms of the at least one holding element that is connected to a rotation shaft such that it co-rotates with the rotation shaft that extends parallel to the X axis. The rotation unit is adapted to assume at least one working position allowing the transport mechanism to have access to the reagent container.