Patents Assigned to Leiden University
  • Patent number: 7807369
    Abstract: The current invention provides improved methods and means for the treatment of virally induced intraepithelial neoplasias of the ano-genital tract, such as HPV induced vulvar-, cervical-, vaginal-, penile- and anal intraepithelial neoplasias (VIN, CIN, VAIN, PIN and AIN). The invention provides a method of treatment of a subject suffering from an anogenital intraepithelial neoplasia comprising at least the steps of first determining whether the subject has a T-cell reactivity for viral early antigens, in particular high risk type HPV antigens; and subsequently a local treatment of the neoplasia with immune modulating compounds eliciting local inflammation if the subject scores positive for the T-cell reactivity, preferably a CD4+response against HPV early antigens. The invention also comprises methods and means to induce or further stimulate a cellular immune response against HPV antigens, prior to or during treatment with the immune modulating compound capable of eliciting a local inflammatory response.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: October 5, 2010
    Assignee: Leiden University Medical Center
    Inventors: Sjoerd Hendricus van der Burg, Rienk Offringa, Cornelis Johannes Maria Melief, Theodorus Jozef Maria Helmerhorst
  • Patent number: 7781432
    Abstract: Analogs or derivatives of nitrobenzylthioinosine corresponding to formula I: in which R represents an unsubstituted or mono- or polysubstituted phenyl, benzyl or heteroaryl group or a phenyl group condensed with heteroaryl, and R? represents an unsubstituted or mono- or polysubstituted NH—C1-6-alkyl, NH-aryl, NH-heteroaryl, NH—C3-8-cycloalkyl, NH—C1-3-alkyl-aryl, NH—C1-3-alkyl-heteroaryl, N(C1-6-alkyl)2, N(C1-3-alkyl-aryl)2, N(C1-3-alkyl-heteroaryl)2, piperidine, piperazine, morpholine or pyrrolidine group; pharmaceutical compositions comprising such analogs or derivatives, and the use of such analogs or derivatives for treating pain and/or various other diseases.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: August 24, 2010
    Assignees: Gruenenthal GmbH, Leiden University
    Inventors: Adriaan Pieter Ijzermann, Reynier Tromp
  • Publication number: 20090220473
    Abstract: The invention relates to the field of stem cell transplantations, immunotherapy and prophylaxis of neoplastic disease. Provided are peptides comprising an amino acid sequence encoded by an open reading frame as present in the nucleotide sequence of a transcript of a naturally occurring hADIR allele, wherein the amino acid sequence comprises a polymorphic MHC class I or II minor histocompatibility binding peptide.
    Type: Application
    Filed: February 22, 2007
    Publication date: September 3, 2009
    Applicant: Leiden University Medical Center
    Inventors: Cornelis Adreanus Maria Van Bergen, Michel George Dideric Kester, Petrus Antonius Van Veelen, Johan Herman Frederik Falkenburg
  • Patent number: 7550138
    Abstract: The invention relates to the production of new Plasmodium mutants which are defective in the expression of the protein P36p. These mutants are unable to cause malaria, yet they can be used as vaccine, giving long lasting protection against infections with wild-type Plasmodium.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: June 23, 2009
    Assignees: Leiden University Medical Center, Stichting Katholieke Universiteit Nijmegen
    Inventors: Andrew Paul Waters, Christofel Jan Janse, Melissa Ruth van Dijk, Robert W. Sauerwein
  • Patent number: 7358235
    Abstract: Analogs or derivatives of nitrobenzylthioinosine compounds. The use of these new analogs of nitrobenzylthioinosine and methods for the treatment of pain and various other indications using these analogs of nitrobenzylthioinosine as well as pharmaceutical compositions including analogs of nitrobenzylthioinosine.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: April 15, 2008
    Assignees: Gruenenthal GmbH, Leiden University
    Inventors: Claudia Puetz, Corinna Sundermann, Bernd Sundermann, Adriaan Pieter Ijzerman, Reynier Tromp, Jacobien Von Frijtag Drabbe Kuenzel
  • Publication number: 20070197528
    Abstract: Analogs or derivatives of nitrobenzylthioinosine, pharmaceutical compositions comprising such analogs or derivatives, and the use of such analogs or derivatives of nitrobenzylthioinosine for the treatment of pain and various other diseases.
    Type: Application
    Filed: December 29, 2006
    Publication date: August 23, 2007
    Applicants: Gruenenthal GmbH, Leiden University
    Inventors: Adriaan Ijzermann, Reynier Tromp
  • Patent number: 6611704
    Abstract: For the early detection of blindness-causing diabetic retinopathy, an apparatus for measuring the autofluorescence of the cornea of an eye, comprising means for tangentially illuminating the cornea, means for receiving the autofluorescent radiation generated in the cornea by this illumination, and means for processing the measured autofluorescent radiation, wherein the means for tangentially illuminating the cornea comprises at least one light source which radiates blue light and at least one filter which transmits at least a part of the blue light in a light path to the cornea, and the means for receiving the autofluorescent radiation generated in the cornea comprises at least one filter which transmits green light.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: August 26, 2003
    Assignee: Leiden University (Medical Center)
    Inventors: Jasper Anton van Best, Franco Docchio
  • Patent number: 5686068
    Abstract: New peptides derived from the MAGE-2 molecule and which bind to HLA-A*0201 molecules are disclosed. Some of these are especially useful because, when complexed to their HLA-A*0201 partner molecules, they induce CTL proliferation.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: November 11, 1997
    Assignees: Ludwig Institute for Cancer Research, Leiden University
    Inventors: Cornelius J. M. Melief, M. W. Visseren, Sjoerd van der Burg, Pierre van der Bruggen, Thierry Boon-Falleur