Abstract: Device for intrauterine use comprising means (7, 8) for attaching the device to the interior wall of the uterus, as well as a member (1) releasing active agent and connected to the said attachment means. The invention is characterized in that the active agent releasing member (1) is in the form of a closed container enclosing the active agent, the walls of the container being at least partly permeable to the active agent.

Abstract: An ultrasonic processing method by which polymer/drug composites can be quickly and efficiently molded to form matrix-type drug delivery systems is disclosed. The advantages of the method include speed and good control of the process. It also causes less degradation in polymers and/or drugs than most conventional processing methods.

Abstract: The invention concerns a process for the preparation of sennosides A and B, wherein rheinanthrone-8-glucoside is oxidized with oxygen or an oxygen source to the sennosides A and B. According to the invention, the oxidation is carried out using active carbon as a catalyst, and, if desired, the obtained sennosides A and B are converted to their calcium salts using methanol precipitation from a calcium ion containing aqueous solution.

Abstract: An implant injection device for once-only use includes an elongated implant housing (10), a cannula (11) and a plunger (20) which is longitudinally movable in the implant housing. The surface (21) of the plunger and the inner wall (15) of the implant housing are equipped with interacting projections (22, 12) which permit the plunger to move inwards into the implant housing but which prevent the removal of the plunger from the implant housing.

Abstract: A process for pharmaceutically treating a subject with S-(-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazol e hemihydrate comprising preparing a composition containing the hemihydrate and topically applying the prepared composition to a surface of the subject.

Abstract: In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is enteric coated with a film which dissolves at a pH-value of from 5 to 7.2.

Abstract: The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W.sup.1, W.sup.2, W.sup.3 and W.sup.4 are independently the group OR.sup.1 or the group NR.sup.2 R.sup.3 wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or straight or branched, optionally unsaturated C.sub.1 -C.sub.22 -alkyl, optionally substituted, optionally unsaturated C.sub.3 -C.sub.10 -cycloalkyl, aryl, aralkyl or silyl SiR.sub.3, or the groups R.sup.2 and R.sup.3 form together with the adjacent nitrogen atom a 3 to 10-membered saturated, partly saturated or aromatic heterocyclic ring, wherein in addition to the nitrogen atom, there may be one or two heteroatoms from the group N, O and S, provided that in formula (I) at least one of the groups W.sup.1, W.sup.2, W.sup.3 and W.sup.4 is hydroxy and at least one of the groups W.sup.1, W.sup.2, W.sup.3 and W.sup.4 is amino group NR.sup.2 R.sup.3, Q.sup.1 and Q.sup.

Abstract: Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently are straight or branched, optionally unsaturated C.sub.1 -C.sub.10 -alkyl, optionally unsaturated C.sub.3 -C.sub.10 -cycloalkyl, aryl, aralkyl, silyl SiR.sub.3 or hydrogen, whereby in formula (I) at least one of the groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 is hydrogen and at least one of the groups is different from hydrogen, Q.sup.1 is hydrogen, hydroxyl, halogen, amino NH.sub.2, or OR', wherein R' is C.sub.1 -C.sub.4 -lower alkyl or acyl, Q.sup.2 is straight or branched, optionally unsaturated C.sub.1 -C.sub.10 -alkyl, -hydroxyalkyl or -aminoalkyl, whereby the oxygen may, as a substituent, contain one group or the nitrogen as a substituent may contain one or two groups, which are C.sub.1 -C.sub.4 -lower alkyl or acyl, or the two substituents of the nitrogen form together with the nitrogen atom a saturated, partly saturated or an aromatic heterocyclic ring, or Q.sup.

Abstract: The invention relates to a process for producing a cyclosporin, especially cyclosporin A, by cultivating the strain (LEA3) of the novel Tolypocladium species aerobically at a temperature of 20.degree.-30 .degree. C. in a nutrient medium containing carbon sources, nitrogen sources and mineral salts, and, if desired, isolating and purifying the resulting cyclosporin.

Abstract: A method of enhancing the formation of bone tissue and/or eliminating late complications subsequent to bone surgery comprising administering an amount, which is safe and sufficient to promote the formation of bone tissue and/or eliminate late complications, of a compound of formula ##STR1## wherein X is H, OH, Cl, F or a methyl group and Y is Cl, OH, --(CH.sub.2).sub.2 --N(CH.sub.3)--(CH.sub.2).sub.4 --CH.sub.3, --(CH.sub.2).sub.n --CH.sub.3 or --(CH.sub.2).sub.n --NH.sub.2, wheren is zero or an integer of 1 to 8, --NHZ, where Z is pyridinyl or cycloheptyl, --SZ', where Z' is pyridinyl or chloro-substituted phenyl, or Y is a pyridinylsubstituted lower alkyl chain; or a non-toxic, pharmaceutically acceptable salt or ester thereof to a bone surgery patient.

Abstract: The invention relates to a method and an equipment for inserting a tubular medicinal capsule on a support. In accordance with the invention, the opening extending through the capsule is expanded by blowing pressurized air into the opening immediately ahead the support being inserted into the opening. After the capsule has entered into its position, the pressurization is relieved, whereby the capsule opening contracts and locks the capsule on the support.

Abstract: Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R.sup.1 -R.sup.4 independently are C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, aryl, aralkyl, silyl SiR.sub.3 or hydrogen, whereby in formula (I) at least one of the groups R.sup.1 -R.sup.4 is hydrogen and at least one of the groups R.sup.1 -R.sup.4 is different from hydrogen, Q.sup.1 is hydrogen, hydroxyl, halogen, amino NH.sub.2, or OR'.sub.1, wherein R'.sub.1 is C.sub.1 -C.sub.4 -alkyl or acyl, Q.sup.2 is the group (.alpha.) wherein Y is a six-membered heterocyclic group, or a carbocyclic aromatic group, X is a bond, O, S or NR'", wherein R'" is hydrogen, lower alkyl, or acyl, n is the integer 0 to 6, and R' and R" are hydrogen or lower alkyl provided that as a ring atom of the ring Y and/or a chain atom of the group X, there is always at least one heteroatom from the group O, N and S, including the steroisomers and the salts of the compounds.

Abstract: Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently are C.sub.1 -C.sub.22 -alkyl, C.sub.2 -C.sub.22 -alkenyl, C.sub.2 -C.sub.22 -alkynyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, aralkyl, silyl and hydrogen, and R.sup.4 is different from hydrogen, Q.sup.1 is hydrogen, fluorine, chlorine, bromine or iodine, and Q.sup.2 is chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and optically active isomers, of the compounds, as well as the pharmaceutically acceptable salts of the compounds.

Abstract: The invention relates to providing a medicinal rod with a shell. The shell is formed from a hose, which is expanded by pressurizing its inner space. The medicinal rod is pushed into the expanded hose, after which the pressure is relieved. The hose tightens over the rod after the pressure relief.

Abstract: Apparatus for filling a plurality of capsules with a selected medicine, the capsules each having a closed lower end and an open top end and being mounted in the apparatus for filling the medicine into the capsules through the open top end, the apparatus comprising a dosing mechanism which separately measures a selected quantity of the medicine for input into each capsule; a capsule filling mechanism comprising a plurality of funnels each having an axis, the funnels each receiving a measured quantity of medicine and funneling the received medicine to an open delivery end of the funnels; the capsules being mounted such that the open top ends of the capsules are disposed at the open delivery ends of the funnels for receipt of the measured quantities of medicine; the filling mechanism further comprising a plurality of spiral spring mechanisms, the spiral spring mechanisms being insertable through the open top ends and removable from the capsules, the spiral spring mechanisms further being rotatable simultaneously

Abstract: Apparatus for manufacturing a subcutaneous capsules filled with a selected medicine comprising: a tube cutting mechanism which cuts a continuous length of tubing into a plurality of tubular capsules, each capsule having an open top end and an open bottom end; a capsule support mechanism which holds the capsules in a predetermined array, the bottom open ends of the capsules being sealed by a sealing mechanism; a plurality of spring mechanisms insertable into the open top ends of each capsule held in the array, each spring mechanism receiving a selected quantity of medicine for each capsule, each spring mechanism being rotatable and delivering the selected quantities of medicine into each capsule by insertion of the spring mechanisms into the open top ends of each capsule and rotation of the spring mechanisms.

Abstract: The invention relates to a device intended for measuring a dose of powdered medicament for inhalation, including a medicament container (1), through which extends a shaft (3) provided with at least one dosage recess (5). Container (1) is provided with at least one flap-like sweeper element (4), resting on shaft (3) in alignment with the dosage recess and having one of its ends rotatable around shaft (3), the other end of said flap dragging along the shaft surface, whereafter said shaft (3) is displaceable in this longitudinal direction relative to container (1) so as to bring dosage recess (5), along with a dose of the medicament carried therein, outside container (1). The invention relates also to the measuring of a dose of powdered medicament for inhalation by using the device described above.

Abstract: The present invention concerns a novel process for the preparation of methylenebisphosphonic acids of the formula I ##STR1## wherein Q.sup.1 and Q.sup.2 are independently hydrogen or halogen, by hydrolyzing the corresponding methylenebisphosphonic acid tetraester of the formula ##STR2## wherein R has the meaning of a straight or branched alkyl group containing 1 to 4 carbon atoms, and Q.sup.1 and Q.sup.2 have the same meaning as above.

Abstract: A novel compound and compositions containing S-(-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5 thiadiazole hemihydrate useful for administration to a patient particularly for topical administration as a pharmaceutical agent for treating known conditions and disorders treatable with timolol.

Abstract: The invention relates to an aerosol nozzle, comprising a socket (1) provided with an abutment surface for a hollow stem (2) in an aerosol container and therebelow an expansion chamber (3) with a nozzle orifice (4) in its wall. The distance between the bottom edge of nozzle orifice (4) and the abutment surface of socket (1) in the longitudinal direction of the socket does not exceed the outer radius of the hollow tube and that the nozzle orifice is located within a wall area defined by the end edge of the hollow tube and the intersecting line between such a cone and the wall of expansion chamber (3), which cone contacts the inner edge of the hollow stem, has its apex inside the hollow stem on its center line, and has a cone angle of 40.degree..