Patents Assigned to Leisure, Inc.
  • Patent number: 11808777
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 7, 2023
    Assignee: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11808776
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 7, 2023
    Assignee: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11234479
    Abstract: A footwear device is provided having a deformable heel contact member. The heel contact member extends above a top portion of the footwear's sole and deforms into a cavity formed in the sole when the user's heel applies a force against the heel contact member. The heel contact member is resilient and returns to its original shape when the force against the heel contact member is eliminated. The heel contact member is particularly well suited to reduce heel slap of open heeled footwear.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: February 1, 2022
    Assignee: Leisure, Inc.
    Inventor: Louis F. Polk
  • Publication number: 20210073918
    Abstract: There are included: an examination result acquisition unit configured to acquire a result of a specimen examination using a specimen examination kit for a specimen examination subject; a health degree computation unit configured to derive a health degree of the specimen examination subject based on the result of the specimen examination, the health degree indicating a health state related to insurance subscription; an insurance information acquisition unit configured to acquire insurance information including an insurance premium based on the health degree of the specimen examination subject, from an insurance premium calculation device configured to calculate the insurance premium based on the health degree; an insurance proposition creation unit configured to create an insurance proposition including the insurance information; and an insurance proposition output unit configured to output the insurance proposition.
    Type: Application
    Filed: November 10, 2020
    Publication date: March 11, 2021
    Applicants: FUJIFILM Corporation, LEISURE, INC.
    Inventors: Yasuhisa KANEKO, Masakazu SUZUKI
  • Publication number: 20200319216
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: April 28, 2020
    Publication date: October 8, 2020
    Applicant: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20200319215
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: April 28, 2020
    Publication date: October 8, 2020
    Applicant: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 10712354
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: July 14, 2020
    Assignee: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20200037695
    Abstract: A footwear device is provided having a deformable heel contact member. The heel contact member extends above a top portion of the footwear's sole and deforms into a cavity formed in the sole when the user's heel applies a force against the heel contact member. The heel contact member is resilient and returns to its original shape when the force against the heel contact member is eliminated. The heel contact member is particularly well suited to reduce heel slap of open heeled footwear.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 6, 2020
    Applicant: Leisure, Inc.
    Inventor: Louis F. Polk
  • Patent number: 10441021
    Abstract: A footwear device is provided having a deformable heel contact member. The heel contact member extends above a top portion of the footwear's sole and deforms into a cavity formed in the sole when the user's heel applies a force against the heel contact member. The heel contact member is resilient and returns to its original shape when the force against the heel contact member is eliminated. The heel contact member is particularly well suited to reduce heel slap of open heeled footwear.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: October 15, 2019
    Assignee: Leisure, Inc.
    Inventor: Louis F. Polk
  • Patent number: 10241012
    Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: March 26, 2019
    Assignee: Leisure, Inc.
    Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa
  • Patent number: 10238983
    Abstract: A wobbling toy is configured to spontaneously re-orient itself in an upright position solely under the force of gravity. The self-righting toy includes a weight that is confined to and movable along a pathway such that the weight defines a dynamic mass that is sufficient to cause the housing to spontaneously pivot along a convex outer surface profile in coordination with a position of the weight in the pathway. The self-righting toy is configured to maintain a positional relationship of the weight so that the housing is spontaneously pivotable along the convex surface without external force supplied by a user.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 26, 2019
    Assignee: Leisure, Inc.
    Inventor: Louis Frederick Polk
  • Publication number: 20170205433
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: July 6, 2015
    Publication date: July 20, 2017
    Applicant: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20170131189
    Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 11, 2017
    Applicant: Leisure, Inc.
    Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa
  • Patent number: 7323144
    Abstract: A simplified collecting operation of a biological sample is provided, which enables reduction of the examination cost.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: January 29, 2008
    Assignee: Leisure, Inc.
    Inventors: Kousuke Arai, Noriyuki Nomura
  • Patent number: 6936473
    Abstract: The present invention is directed to a method of preparing a biological sample for quantification which includes an element to be quantified. A volume of biological sample is collected without quantifying the volume thereof to mix with a specified volume of an aqueous solution. Absorptivity of an indicating material in the aqueous solution is measured. Absorptivity of the indicating material in the collected biological sample mixed with the specified volume of the aqueous solution is measured. Next, a dilution ratio of the biological sample is calculated using the absorptivity of the indicating material in the specified volume of the aqueous solution and the absorptivity of the indicating material in the biological sample mixed with the specified volume of the aqueous solution.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: August 30, 2005
    Assignee: Leisure, Inc.
    Inventors: Hiromi Nanba, Osamu Koga, Masatoshi Horita, Yoshio Ohta
  • Publication number: 20040141888
    Abstract: An object of the present invention is to reduce the cost in blood test and to simplify the operation thereof.
    Type: Application
    Filed: January 7, 2004
    Publication date: July 22, 2004
    Applicant: LEISURE, INC.
    Inventors: Hiromi Nanba, Osamu Koga, Masatoshi Horita, Yoshio Ohta
  • Patent number: 6406347
    Abstract: A bubble forming mechanism has a bottle for holding therein a bubble forming solution. The bottle has a concave top surface with a slot formed in the surface. The bottle also includes a guide carried by a portion of the bottle. The mechanism has a wand with a loop carried on a lower end of the wand wherein the wand and loop are capable of being received in the slot and into the bottle. The guide aligns the wand and the loop with the slot.
    Type: Grant
    Filed: February 10, 2001
    Date of Patent: June 18, 2002
    Assignee: Leisure, Inc.
    Inventors: Darrin Swagel, Steven Huebl, Neil Amundsen, Martijn Loerakker, Patrick Sheridan
  • Publication number: 20010029145
    Abstract: A bubble forming mechanism has a bottle for holding therein a bubble forming solution. The bottle has a concave top surface with a slot formed in the surface. The bottle also includes a guide carried by a portion of the bottle. The mechanism has a wand with a loop carried on a lower end of the wand wherein the wand and loop are capable of being received in the slot and into the bottle. The guide aligns the wand and the loop with the slot.
    Type: Application
    Filed: February 10, 2001
    Publication date: October 11, 2001
    Applicant: Leisure, Inc.
    Inventors: Darrin Swagel, Steven Huebl, Neil Amundsen, Martijn Loerakker, Patrick Sheridan
  • Patent number: D517442
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: March 21, 2006
    Assignee: Leisure, Inc.
    Inventor: Louis F. Polk, III
  • Patent number: D410986
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: June 15, 1999
    Assignee: Leisure, Inc.
    Inventors: Adam A. Luedke, Louis F. Polk, III, Kim M. Parmater