Patents Assigned to Leisure, Inc.
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Patent number: 11808777Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: GrantFiled: April 28, 2020Date of Patent: November 7, 2023Assignee: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11808776Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: GrantFiled: April 28, 2020Date of Patent: November 7, 2023Assignee: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11234479Abstract: A footwear device is provided having a deformable heel contact member. The heel contact member extends above a top portion of the footwear's sole and deforms into a cavity formed in the sole when the user's heel applies a force against the heel contact member. The heel contact member is resilient and returns to its original shape when the force against the heel contact member is eliminated. The heel contact member is particularly well suited to reduce heel slap of open heeled footwear.Type: GrantFiled: October 14, 2019Date of Patent: February 1, 2022Assignee: Leisure, Inc.Inventor: Louis F. Polk
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Publication number: 20210073918Abstract: There are included: an examination result acquisition unit configured to acquire a result of a specimen examination using a specimen examination kit for a specimen examination subject; a health degree computation unit configured to derive a health degree of the specimen examination subject based on the result of the specimen examination, the health degree indicating a health state related to insurance subscription; an insurance information acquisition unit configured to acquire insurance information including an insurance premium based on the health degree of the specimen examination subject, from an insurance premium calculation device configured to calculate the insurance premium based on the health degree; an insurance proposition creation unit configured to create an insurance proposition including the insurance information; and an insurance proposition output unit configured to output the insurance proposition.Type: ApplicationFiled: November 10, 2020Publication date: March 11, 2021Applicants: FUJIFILM Corporation, LEISURE, INC.Inventors: Yasuhisa KANEKO, Masakazu SUZUKI
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Publication number: 20200319216Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: April 28, 2020Publication date: October 8, 2020Applicant: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20200319215Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: April 28, 2020Publication date: October 8, 2020Applicant: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 10712354Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: GrantFiled: July 6, 2015Date of Patent: July 14, 2020Assignee: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20200037695Abstract: A footwear device is provided having a deformable heel contact member. The heel contact member extends above a top portion of the footwear's sole and deforms into a cavity formed in the sole when the user's heel applies a force against the heel contact member. The heel contact member is resilient and returns to its original shape when the force against the heel contact member is eliminated. The heel contact member is particularly well suited to reduce heel slap of open heeled footwear.Type: ApplicationFiled: October 14, 2019Publication date: February 6, 2020Applicant: Leisure, Inc.Inventor: Louis F. Polk
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Patent number: 10441021Abstract: A footwear device is provided having a deformable heel contact member. The heel contact member extends above a top portion of the footwear's sole and deforms into a cavity formed in the sole when the user's heel applies a force against the heel contact member. The heel contact member is resilient and returns to its original shape when the force against the heel contact member is eliminated. The heel contact member is particularly well suited to reduce heel slap of open heeled footwear.Type: GrantFiled: June 22, 2017Date of Patent: October 15, 2019Assignee: Leisure, Inc.Inventor: Louis F. Polk
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Patent number: 10241012Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.Type: GrantFiled: June 12, 2014Date of Patent: March 26, 2019Assignee: Leisure, Inc.Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa
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Patent number: 10238983Abstract: A wobbling toy is configured to spontaneously re-orient itself in an upright position solely under the force of gravity. The self-righting toy includes a weight that is confined to and movable along a pathway such that the weight defines a dynamic mass that is sufficient to cause the housing to spontaneously pivot along a convex outer surface profile in coordination with a position of the weight in the pathway. The self-righting toy is configured to maintain a positional relationship of the weight so that the housing is spontaneously pivotable along the convex surface without external force supplied by a user.Type: GrantFiled: January 13, 2017Date of Patent: March 26, 2019Assignee: Leisure, Inc.Inventor: Louis Frederick Polk
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Publication number: 20170205433Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: July 6, 2015Publication date: July 20, 2017Applicant: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20170131189Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.Type: ApplicationFiled: June 12, 2014Publication date: May 11, 2017Applicant: Leisure, Inc.Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa
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Patent number: 7323144Abstract: A simplified collecting operation of a biological sample is provided, which enables reduction of the examination cost.Type: GrantFiled: March 7, 2003Date of Patent: January 29, 2008Assignee: Leisure, Inc.Inventors: Kousuke Arai, Noriyuki Nomura
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Patent number: 6936473Abstract: The present invention is directed to a method of preparing a biological sample for quantification which includes an element to be quantified. A volume of biological sample is collected without quantifying the volume thereof to mix with a specified volume of an aqueous solution. Absorptivity of an indicating material in the aqueous solution is measured. Absorptivity of the indicating material in the collected biological sample mixed with the specified volume of the aqueous solution is measured. Next, a dilution ratio of the biological sample is calculated using the absorptivity of the indicating material in the specified volume of the aqueous solution and the absorptivity of the indicating material in the biological sample mixed with the specified volume of the aqueous solution.Type: GrantFiled: November 29, 2001Date of Patent: August 30, 2005Assignee: Leisure, Inc.Inventors: Hiromi Nanba, Osamu Koga, Masatoshi Horita, Yoshio Ohta
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Publication number: 20040141888Abstract: An object of the present invention is to reduce the cost in blood test and to simplify the operation thereof.Type: ApplicationFiled: January 7, 2004Publication date: July 22, 2004Applicant: LEISURE, INC.Inventors: Hiromi Nanba, Osamu Koga, Masatoshi Horita, Yoshio Ohta
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Patent number: 6406347Abstract: A bubble forming mechanism has a bottle for holding therein a bubble forming solution. The bottle has a concave top surface with a slot formed in the surface. The bottle also includes a guide carried by a portion of the bottle. The mechanism has a wand with a loop carried on a lower end of the wand wherein the wand and loop are capable of being received in the slot and into the bottle. The guide aligns the wand and the loop with the slot.Type: GrantFiled: February 10, 2001Date of Patent: June 18, 2002Assignee: Leisure, Inc.Inventors: Darrin Swagel, Steven Huebl, Neil Amundsen, Martijn Loerakker, Patrick Sheridan
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Publication number: 20010029145Abstract: A bubble forming mechanism has a bottle for holding therein a bubble forming solution. The bottle has a concave top surface with a slot formed in the surface. The bottle also includes a guide carried by a portion of the bottle. The mechanism has a wand with a loop carried on a lower end of the wand wherein the wand and loop are capable of being received in the slot and into the bottle. The guide aligns the wand and the loop with the slot.Type: ApplicationFiled: February 10, 2001Publication date: October 11, 2001Applicant: Leisure, Inc.Inventors: Darrin Swagel, Steven Huebl, Neil Amundsen, Martijn Loerakker, Patrick Sheridan
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Patent number: D517442Type: GrantFiled: February 19, 2004Date of Patent: March 21, 2006Assignee: Leisure, Inc.Inventor: Louis F. Polk, III
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Patent number: D410986Type: GrantFiled: May 7, 1998Date of Patent: June 15, 1999Assignee: Leisure, Inc.Inventors: Adam A. Luedke, Louis F. Polk, III, Kim M. Parmater