Patents Assigned to LEK Pharmaceutical & Chemical Co., DD
  • Preparation of clavulanate salts
    Patent number: 6369219
    Abstract: Provided is a process for purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including adding an additional solvent to a solution of clavulanic acid in water immiscible solvent; contacting the solution with an amine; isolating the amine salt of the clavulanic acid formed; and converting the amine into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: April 9, 2002
    Assignee: LEK Pharmaceutical & Chemical Co. DD
    Inventor: Egidij Capuder
  • Preparation of clavulanate salts
    Publication number: 20010025104
    Abstract: ? Provided is a process for purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including adding an additional solvent to a solution of clavulanic acid in water immiscible solvent; contacting the solution with an amine; isolating the amine salt of the clavulanic acid formed; and converting the amine into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: December 14, 2000
    Publication date: September 27, 2001
    Applicant: Lek Pharmaceutical & Chemical Co. DD.
    Inventor: Egidij Capuder
  • Preparation of clavulanate salts
    Patent number: 6180782
    Abstract: Provided is a process for purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including adding an additional solvent to a solution of clavulanic acid in water immiscible solvent; contacting the solution with an amine; isolating the amine salt of the clavulanic acid formed; and converting the amine into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: January 30, 2001
    Assignee: LEK Pharmaceutical & Chemical Co., DD
    Inventor: Egidij Capuder
  • Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804
    Patent number: 5985625
    Abstract: A process for the isolation of clavulanic acid pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microogranism comprises the microfiltration of the broth without prior treatment.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: November 16, 1999
    Assignee: Lek Pharmaceutical & Chemical Co. dd
    Inventor: Egidij Capuder