Patents Assigned to LEK, tovarna, farmacevtskih in Kemicnih . . .
  • Sodium alumoglucoheptonate and a process for its preparation
    Patent number: 4297293
    Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.
    Type: Grant
    Filed: February 6, 1980
    Date of Patent: October 27, 1981
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov. n.sol.o.
    Inventors: Peter Suhac, Natasa Hafner-Milac, Bozidar Dolenc
  • Process for preparing 2-(3-benzoylphenyl)-propionic acid
    Patent number: 4230884
    Abstract: Process for preparing 2-(3-benzoylphenyl)-propionic acid or salt thereof which includes methylating 3-benzoyl-phenyl acetonitrile or an alkoxide thereof in the presence of neutral non-cyclic ligands with an open polyether chain.
    Type: Grant
    Filed: April 10, 1979
    Date of Patent: October 28, 1980
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Boris Zupancic, Mirko Sopoic
  • Process for the preparation of N-substituted esters of 9,10-dihydrolysergicacids
    Patent number: 4230859
    Abstract: A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: ##STR1## wherein R.sub.1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms,R.sub.2 is hydrogen or an alkoxy group of 1-3 carbon atoms andX' is hydrogen or halogen,characterized in that esterified 9,10-dihydrolysergic acids of the formula: ##STR2## wherein R is hydrogen or a hydrolyzable organic group,X' is hydrogen or halogen, andR.sub.2 has the meaning as stated above,are reacted with a compound of the formula:R.sub.1 Y (III)whereinR.sub.1 has the meaning as stated above,Y is halogen or sulphate,in the presence of a catalyst for phase transition in the presence of aqueous alkali medium in an inert organic solvent immiscible with water, and certain novel esters obtained thereby.
    Type: Grant
    Filed: July 7, 1978
    Date of Patent: October 28, 1980
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventor: Rudolf Rucman
  • Process for the preparation of 2-(3-benzoylphenyl)-propionic acid
    Patent number: 4201870
    Abstract: A process for the preparation of 2-(3-benzoylphenyl)propionic acid or salt thereof wherein 3-benzoylphenyl acetonitrile or an alkoxide thereof is reacted with a methylating agent and wherein the mixture obtained is hydrolized to thereby provide the desired acid.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: May 6, 1980
    Assignee: LEK Tovarna Farmacevtskih in Kemicnih Izdelkov, n.sol.o.
    Inventor: Boris Zupancic
  • Process for preparing N-cyano-N'methyl-N"-{2-[(4-methyl-5-imidazolyl)-methylthio]-ethyl} guanidine
    Patent number: 4200761
    Abstract: A process of preparing ##STR1## by reacting 4-thiomethyl-5-methyl imidazole with N-cyano-N'-methyl-N"-(2-chloroethyl) guanidine in a two-phase system under the conditions of phase transfer catalysis.
    Type: Grant
    Filed: April 18, 1979
    Date of Patent: April 29, 1980
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Branko Jenko, Igor Langof, Joza Habjan
  • Process for the preparation of 2-(3-benzoylphenyl)-propionic acid
    Patent number: 4162364
    Abstract: A process for preparing 2-(3-benzoylphenyl)-propionic acid which includes treating 1-(3-benzoylphenyl)-propine with a thallium (III) salt in a lower alkanol to obtain 2-(3-benzoylphenyl)-propionic ester, and hydrolyzing the ester.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: July 24, 1979
    Assignee: LEK Tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Boris Zupancic, Branko Jenko
  • 10171977
    Patent number: 4147729
    Abstract: 1-(3-Benzoylphenyl)-propine represented by the formula: ##STR1## useful as an intermediate is provided.
    Type: Grant
    Filed: April 3, 1979
    Date of Patent: April 3, 1979
    Assignee: LEK tovarna farmacevtskih in kemicnih izdelkov, n.sol.o
    Inventors: Boris Zupancic, Branko Jenko
  • Process for preparing .beta.-methyldigoxin
    Patent number: 4145528
    Abstract: Preparation of .beta.-methyldigoxin in the presence of dimethyl formamide, an inert solvent, methyl ester of a sulphuric acid, and strontium hydroxide.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: March 20, 1979
    Assignee: LEK tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Borut Pelan, Marija Milohnoja, Magda Pezdirc