Abstract: In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy-1,4-dihydropyridine of the formula ##STR1## 2-nitrobenzaldehyd-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20.degree. and 150.degree. C. The compound is a valuable medicine for the treatment of angina pectoris.
Type:
Grant
Filed:
July 27, 1982
Date of Patent:
August 21, 1984
Assignee:
LEK, Tovarna Farmacevtskih in Kemicnih Izdelkov, N.Sol.O.
Abstract: Medicine containing salts of ergotaminine, ergosinine, ergocryptinine, ergocristinine, and ergocorninine and use for treating arterial hypertension, heart insufficiency, heart arrhythmia or cephalalgia.
Type:
Grant
Filed:
June 2, 1981
Date of Patent:
April 3, 1984
Assignee:
LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Inventors:
Nebojsa Djordjevic, Rudolf Rucman, Suncica Jovanovic, Breda Bole-Vunduk, Tone Lavric, Boza Lavric, Cvetka Gruskovnjak, Ana Kocjan, Hermina Krmelj
Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.
Type:
Grant
Filed:
July 9, 1981
Date of Patent:
October 19, 1982
Assignee:
LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Inventors:
Peter Suhac, Natasa Hafner-Milac, Bozidar Dolenc
Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.
Type:
Grant
Filed:
February 6, 1980
Date of Patent:
October 27, 1981
Assignee:
LEK, tovarna farmacevtskih in kemicnih izdelkov. n.sol.o.
Inventors:
Peter Suhac, Natasa Hafner-Milac, Bozidar Dolenc
Abstract: Process for preparing 2-(3-benzoylphenyl)-propionic acid or salt thereof which includes methylating 3-benzoyl-phenyl acetonitrile or an alkoxide thereof in the presence of neutral non-cyclic ligands with an open polyether chain.
Type:
Grant
Filed:
April 10, 1979
Date of Patent:
October 28, 1980
Assignee:
LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Abstract: A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: ##STR1## wherein R.sub.1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms,R.sub.2 is hydrogen or an alkoxy group of 1-3 carbon atoms andX' is hydrogen or halogen,characterized in that esterified 9,10-dihydrolysergic acids of the formula: ##STR2## wherein R is hydrogen or a hydrolyzable organic group,X' is hydrogen or halogen, andR.sub.2 has the meaning as stated above,are reacted with a compound of the formula:R.sub.1 Y (III)whereinR.sub.1 has the meaning as stated above,Y is halogen or sulphate,in the presence of a catalyst for phase transition in the presence of aqueous alkali medium in an inert organic solvent immiscible with water, and certain novel esters obtained thereby.
Type:
Grant
Filed:
July 7, 1978
Date of Patent:
October 28, 1980
Assignee:
LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Abstract: A process for the preparation of 2-(3-benzoylphenyl)propionic acid or salt thereof wherein 3-benzoylphenyl acetonitrile or an alkoxide thereof is reacted with a methylating agent and wherein the mixture obtained is hydrolized to thereby provide the desired acid.
Type:
Grant
Filed:
October 17, 1977
Date of Patent:
May 6, 1980
Assignee:
LEK Tovarna Farmacevtskih in Kemicnih Izdelkov, n.sol.o.
Abstract: A process of preparing ##STR1## by reacting 4-thiomethyl-5-methyl imidazole with N-cyano-N'-methyl-N"-(2-chloroethyl) guanidine in a two-phase system under the conditions of phase transfer catalysis.
Type:
Grant
Filed:
April 18, 1979
Date of Patent:
April 29, 1980
Assignee:
LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Abstract: A process for preparing 2-(3-benzoylphenyl)-propionic acid which includes treating 1-(3-benzoylphenyl)-propine with a thallium (III) salt in a lower alkanol to obtain 2-(3-benzoylphenyl)-propionic ester, and hydrolyzing the ester.
Type:
Grant
Filed:
October 17, 1977
Date of Patent:
July 24, 1979
Assignee:
LEK Tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Abstract: Preparation of .beta.-methyldigoxin in the presence of dimethyl formamide, an inert solvent, methyl ester of a sulphuric acid, and strontium hydroxide.
Type:
Grant
Filed:
August 10, 1977
Date of Patent:
March 20, 1979
Assignee:
LEK tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Inventors:
Borut Pelan, Marija Milohnoja, Magda Pezdirc