Patents Assigned to LEK, tovarna farmacevtskih
  • Patent number: 4467093
    Abstract: In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy-1,4-dihydropyridine of the formula ##STR1## 2-nitrobenzaldehyd-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20.degree. and 150.degree. C. The compound is a valuable medicine for the treatment of angina pectoris.
    Type: Grant
    Filed: July 27, 1982
    Date of Patent: August 21, 1984
    Assignee: LEK, Tovarna Farmacevtskih in Kemicnih Izdelkov, N.Sol.O.
    Inventors: Branko Jenko, Igor Langof
  • Patent number: 4440772
    Abstract: Medicine containing salts of ergotaminine, ergosinine, ergocryptinine, ergocristinine, and ergocorninine and use for treating arterial hypertension, heart insufficiency, heart arrhythmia or cephalalgia.
    Type: Grant
    Filed: June 2, 1981
    Date of Patent: April 3, 1984
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Nebojsa Djordjevic, Rudolf Rucman, Suncica Jovanovic, Breda Bole-Vunduk, Tone Lavric, Boza Lavric, Cvetka Gruskovnjak, Ana Kocjan, Hermina Krmelj
  • Patent number: 4354940
    Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.
    Type: Grant
    Filed: July 9, 1981
    Date of Patent: October 19, 1982
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Peter Suhac, Natasa Hafner-Milac, Bozidar Dolenc
  • Patent number: 4304929
    Abstract: Preparation of 4-(n-hexadecylamino)-benzoic acid or salt thereof employing as catalyst quaternary ammonium or phosphonium salt.
    Type: Grant
    Filed: March 7, 1980
    Date of Patent: December 8, 1981
    Assignee: LEK tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Branko Jenko, Natasa Hafner-Milac, Joza Habjan, Anton Prosen, Igor Langof
  • Patent number: 4297293
    Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.
    Type: Grant
    Filed: February 6, 1980
    Date of Patent: October 27, 1981
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov. n.sol.o.
    Inventors: Peter Suhac, Natasa Hafner-Milac, Bozidar Dolenc
  • Patent number: 4230884
    Abstract: Process for preparing 2-(3-benzoylphenyl)-propionic acid or salt thereof which includes methylating 3-benzoyl-phenyl acetonitrile or an alkoxide thereof in the presence of neutral non-cyclic ligands with an open polyether chain.
    Type: Grant
    Filed: April 10, 1979
    Date of Patent: October 28, 1980
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Boris Zupancic, Mirko Sopoic
  • Patent number: 4230859
    Abstract: A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: ##STR1## wherein R.sub.1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms,R.sub.2 is hydrogen or an alkoxy group of 1-3 carbon atoms andX' is hydrogen or halogen,characterized in that esterified 9,10-dihydrolysergic acids of the formula: ##STR2## wherein R is hydrogen or a hydrolyzable organic group,X' is hydrogen or halogen, andR.sub.2 has the meaning as stated above,are reacted with a compound of the formula:R.sub.1 Y (III)whereinR.sub.1 has the meaning as stated above,Y is halogen or sulphate,in the presence of a catalyst for phase transition in the presence of aqueous alkali medium in an inert organic solvent immiscible with water, and certain novel esters obtained thereby.
    Type: Grant
    Filed: July 7, 1978
    Date of Patent: October 28, 1980
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventor: Rudolf Rucman
  • Patent number: 4201870
    Abstract: A process for the preparation of 2-(3-benzoylphenyl)propionic acid or salt thereof wherein 3-benzoylphenyl acetonitrile or an alkoxide thereof is reacted with a methylating agent and wherein the mixture obtained is hydrolized to thereby provide the desired acid.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: May 6, 1980
    Assignee: LEK Tovarna Farmacevtskih in Kemicnih Izdelkov, n.sol.o.
    Inventor: Boris Zupancic
  • Patent number: 4200761
    Abstract: A process of preparing ##STR1## by reacting 4-thiomethyl-5-methyl imidazole with N-cyano-N'-methyl-N"-(2-chloroethyl) guanidine in a two-phase system under the conditions of phase transfer catalysis.
    Type: Grant
    Filed: April 18, 1979
    Date of Patent: April 29, 1980
    Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Branko Jenko, Igor Langof, Joza Habjan
  • Patent number: 4162364
    Abstract: A process for preparing 2-(3-benzoylphenyl)-propionic acid which includes treating 1-(3-benzoylphenyl)-propine with a thallium (III) salt in a lower alkanol to obtain 2-(3-benzoylphenyl)-propionic ester, and hydrolyzing the ester.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: July 24, 1979
    Assignee: LEK Tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Boris Zupancic, Branko Jenko
  • Patent number: 4147729
    Abstract: 1-(3-Benzoylphenyl)-propine represented by the formula: ##STR1## useful as an intermediate is provided.
    Type: Grant
    Filed: April 3, 1979
    Date of Patent: April 3, 1979
    Assignee: LEK tovarna farmacevtskih in kemicnih izdelkov, n.sol.o
    Inventors: Boris Zupancic, Branko Jenko
  • Patent number: 4145528
    Abstract: Preparation of .beta.-methyldigoxin in the presence of dimethyl formamide, an inert solvent, methyl ester of a sulphuric acid, and strontium hydroxide.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: March 20, 1979
    Assignee: LEK tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
    Inventors: Borut Pelan, Marija Milohnoja, Magda Pezdirc