Patents Assigned to Leland Stanford Junior University
  • MODULATING BONE MORPHOGENIC PROTEIN (BMP) SIGNALING IN THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20240102022
    Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.
    Type: Application
    Filed: November 17, 2023
    Publication date: March 28, 2024
    Applicants: CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Elizabeth Yang Chen, Felicia Reinitz, Jane Antony, Michael F. Clarke, Robert C. Jones
  • Compositions of Iboga Alkaloids and Methods of Treatment
    Publication number: 20240100061
    Abstract: Compositions comprising an iboga alkaloid and a cardioprotective agent are provided. Use of the compositions in treating neuropsychiatric disorders are described, where the cardioprotective agent is administered before, during and/or after the iboga alkaloid.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 28, 2024
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
    Inventors: Nolan R. Williams, Ian Kratter, AnnaMarie Daniels, Gregory Bird
  • Inducible Production-Phase Promoters for Coordinated Heterologous Expression in Yeast
    Publication number: 20240102030
    Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
    Type: Application
    Filed: September 6, 2023
    Publication date: March 28, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
  • Methods of Treatment With an Iboga Alkaloid
    Publication number: 20240100062
    Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 28, 2024
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
    Inventors: Nolan R. Williams, John Philip Coetzee, Andrew Dedinas Geoly, AnnaMarie Daniels, Gregory Bird
  • INHIBITION OF PROSTAGLANDIN DEGRADING ENZYME 15-PGDH TO IMPROVE JOINT STRUCTURE AND FUNCTION
    Publication number: 20240100027
    Abstract: The present disclosure provides methods of improving the structure and/or function of a joint tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating joint dysfunction and/or degeneration associated with aging, injury, disease, disorder, and/or condition.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 28, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. BLAU, Nidhi BHUTANI, Mamta SINGLA, Adelaida Rosa PALLA
  • Methods and Systems for Analyzing Nucleic Acid Molecules
    Publication number: 20240105281
    Abstract: Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.
    Type: Application
    Filed: August 18, 2023
    Publication date: March 28, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jacob J. Chabon, David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Systems and methods for using mobile and wearable video capture and feedback plat-forms for therapy of mental disorders
    Patent number: 11937929
    Abstract: Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Catalin Voss, Nicholas Joseph Haber, Dennis Paul Wall, Aaron Scott Kline, Terry Allen Winograd
  • Compounding and non-rigid image registration for ultrasound speckle reduction
    Patent number: 11937977
    Abstract: This disclosure relates to ultrasound imaging with reduced speckle. Ultrasound imaging with frequency compounding and angle compounding is disclosed. Techniques are disclosed to make ultrasound imaging with frequency and angle compounding more robust. One such technique is non-rigid image registration to align ultrasound images for angle compounding. Another disclosed technique includes selecting a subset of ultrasound images for non-rigid ultrasound image registration.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noah Yuzo Toyonaga, Yilei Li, Steven Chu
  • Rewiring aberrant cancer signaling to a therapeutic effector response with a synthetic two-component system
    Patent number: 11939609
    Abstract: Compositions and methods for targeted treatment of cancer are disclosed. In particular, the invention relates to methods of targeting anti-cancer therapy to cells exhibiting aberrant signaling associated with cancer pathogenesis by administering synthetic signaling proteins that couple detection of an oncogenic signal to release of therapeutic agents into cancerous cells.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hokyung Chung, Michael Z. Lin
  • Nanotextured metal powders for 3D printing of metals
    Patent number: 11938536
    Abstract: Metal powder particles for use in additive manufacturing are made by removing material from the surface of the particles using wet chemical etching to create a nanoscale texturing of the surface, increasing absorptivity by the metal powder particles of incident laser light and maintaining flowability. The nanoscale texturing has sub-wavelength features at laser wavelengths in the range 800-1100 nm. The particles are substantially spherical and have mean diameters in the range 10-70 ?m.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ottman A. Tertuliano, Philip J. DePond, Andrew Curtis Lee, Xun Gu, Wei Cai, Adrian J. Lew
  • Omega and theta—a method to measure magnetic field at AC frequencies without using current spinning
    Patent number: 11940505
    Abstract: We use the AC Hall effect to characterize a magnetic field at an unknown frequency (or frequencies). The current to the Hall sensor is driven at a known frequency f. The output Hall voltage is characterized in a frequency range from f1 to f2 (with f<f1<f2 and f2?f1<2f). This provides a measurement of the magnetic field in a frequency range from f1?f to f2?f. The resulting measurement of magnetic field spectral components is phase-independent and requires no prior knowledge of exact magnetic field frequency.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anand Vikas Lalwani, Ananth Saran Yalamarthy, Maximillian Holliday, Hannah Alpert, Carla Nicole Pinzon, Debbie G. Senesky
  • Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling
    Patent number: 11938153
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides chimeric antigen receptor (CAR) T cells that are modified to maintain functionality under conditions in which unmodified CAR T cells display exhaustion. Compositions and methods disclosed herein find use in inhibiting or reversing CAR T cell exhaustion (e.g., by modulating CAR surface expression) thereby enhancing CAR T cell function. Compositions and methods of the invention fmd use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rachel Lynn, Crystal Mackall, Tom J. Wandless, Evan Weber
  • GENE CORRECTION FOR SCID-X1 IN LONG-TERM HEMATOPOIETIC STEM CELLS
    Publication number: 20240093242
    Abstract: The present disclosure provides methods and compositions for treating SCID-X1 in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a full-length, codon-optimized IL2RG cDNA at the endogenous IL2RG locus.
    Type: Application
    Filed: August 3, 2021
    Publication date: March 21, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mara Pavel-Dinu, Matthew H. Porteus
  • BLOCKCHAIN SYSTEM FOR CONFIDENTIAL AND ANONYMOUS SMART CONTRACTS
    Publication number: 20240095728
    Abstract: Blockchain-based, smart contract platforms have great promise to remove trust and add transparency to distributed applications. However, this benefit often comes at the cost of greatly reduced privacy. Techniques for implementing a privacy-preserving smart contract is described. The system can keep accounts private while not losing functionality and with only a limited performance overhead. This is achieved by building a confidential and anonymous token on top of a cryptocurrency. Multiple complex applications can also be built using the smart contract system.
    Type: Application
    Filed: November 20, 2023
    Publication date: March 21, 2024
    Applicants: VISA INTERNATIONAL SERVICE ASSOCIATIN, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shashank Agrawal, Karl Benedikt Bünz, Mahdi Zamani, Dan Boneh
  • Electrochemical catalysts with enhanced catalytic activity
    Patent number: 11936051
    Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: March 19, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaf
    Inventors: Friedrich B. Prinz, Shicheng Xu, Yongmin Kim, Thomas Jaramillo, Drew C. Higgins, Maha Yusuf, Zhaoxuan Wang, Kyung Min Lee, Marat Orazov, Dong Un Lee, Tanja Graf, Thomas Schladt, Gerold Huebner, Hanna-Lena Wittern, Jonathan Edward Mueller
  • Contrast dose reduction for medical imaging using deep learning
    Patent number: 11935231
    Abstract: A method for diagnostic imaging with reduced contrast agent dose uses a deep learning network (DLN) [114] that has been trained using zero-contrast [100] and low-contrast [102] images as input to the DLN and full-contrast images [104] as reference ground truth images. Prior to training, the images are pre-processed [106, 110, 118] to co-register and normalize them. The trained DLN [114] is then used to predict a synthesized full-dose contrast agent image [116] from acquired zero-dose and low-dose images.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Greg Zaharchuk, Enhao Gong, John M. Pauly
  • Immolative cell-penetrating complexes for nucleic acid delivery to the lung
    Patent number: 11931416
    Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim R. Blake, Paul Wender, Robert M. Waymouth, Ronald Levy, Ole Audun Werner Haabeth, Rebecca McClellan, Adrienne Sallets
  • Systems and Methods for Targeted Neuromodulation
    Publication number: 20240081920
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • Systems and Methods for Generating Knowledge Graphs and Text Summaries from Document Databases
    Publication number: 20240086444
    Abstract: Systems and methods for generating knowledge graphs and text summaries from document databases are provided. In one embodiment, a system for generating knowledge graphs and text summaries includes: a device, including: a processor; and a memory containing a knowledge graph and text summary generating application, where the knowledge graph and text summary generating application directs the processor to: query a global network of biomedical relationships; construct a knowledge graph and a citation graph; apply processes to learn local context-based weights and compute summarizations; and provide results via a display.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Stefano Emanuele Rensi
  • CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION
    Publication number: 20240084335
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: September 29, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal