Abstract: The invention provides a method for validating the functioning of an apparatus with a static mixing device for mixing two liquid streams for producing nanoparticles. The static mixing device may be a jet impingement reactor. The method is based on the use of PLA, PLG or PLGA for producing polymeric nanoparticles with highly reproducible particle sizes. The invention further provides kits and liquid compositions for carrying out the method.

Abstract: Nanoparticles including tacrolimus, and a method for providing nanoparticles including tacrolimus as well as to nanoparticles including tacrolimus that are obtainable by said method. Also relates to the nanoparticles including tacrolimus for use as a medicament. Further relates to a mucoadhesive buccal film containing the nanoparticles including tacrolimus and the mucoadhesive buccal film for use as a medicament, especially in pediatric patients.

Abstract: A fluid reactor for generating particulate fluids by collision, has a housing which encloses a collision chamber, a first fluid nozzle, and a second fluid nozzle oriented opposite thereto in a collinear manner, which is located directly opposite the first fluid nozzle in a jet direction of the first and second fluid nozzles in a common collision zone, at least one rinsing fluid inlet into the collision chamber arranged on a first side of the first fluid nozzle, and at least one product outlet out of the collision chamber arranged on a second side of the second fluid nozzle.