Patents Assigned to Les Hopitaux Universitaires De Geneve
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Patent number: 11649455Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: GrantFiled: April 1, 2019Date of Patent: May 16, 2023Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
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Patent number: 11613747Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: GrantFiled: April 1, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
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Publication number: 20210095278Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: ApplicationFiled: April 1, 2019Publication date: April 1, 2021Applicants: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz KRAUSE, Francis ROUSSET, Patrick SALMON, Marco ALESSANDRINI, Roberto SPECK, Simon BREDL, Tafadzwa MLAMBO, Renier MYBURGH
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Patent number: 10806739Abstract: The present invention is directed to N-desmethylclobazam or any suitable pharmaceutically acceptable thereof useful for the prevention and/or treatment of a chronic pain disorder and related methods and pharmaceutical formulations.Type: GrantFiled: March 2, 2016Date of Patent: October 20, 2020Assignees: LES HOPITAUX UNIVERSITAIRES DE GENEVE, UNIVERSITAT ZURICH, UNIVERSITE DE GENEVEInventors: Jules Desmeules, Hanns Ulrich Zeilhofer, Marie Besson, Youssef Daali, Alain Matthey, William T. Ralvenius
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Patent number: 10772875Abstract: The present invention relates to agents enhancing HuR/ELAV levels for use in the treatment of BRAF-mutated cancers and uses thereof. In particular, the invention relates to the use of agents enhancing HuR/ELAV levels in combination with BRAF inhibitors for the treatment of BRAF-mutated cancers, in particular melanoma and to methods for identifying agents useful for potentiating the effects of BRAF inhibitors, when used in combination.Type: GrantFiled: March 14, 2018Date of Patent: September 15, 2020Assignee: LES HOPITAUX UNIVERSITAIRES DE GENEVEInventor: Rastine Mérat
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Patent number: 10087234Abstract: The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.Type: GrantFiled: November 6, 2013Date of Patent: October 2, 2018Assignees: LES HOPITAUX UNIVERSITAIRES DE GENEVE, UNIVERSITE DE GENEVE, HOFFMAN-LA ROCHE INC.Inventors: Nicolas Vuilleumier, Sabrina Pagano, Oliver Hartley, Hubert Gaertner, Priscila Camillo Teixeira, Paul Cutler, Philippe Ferber
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Patent number: 9724212Abstract: Implant for transfemoral or transtibial amputation comprising a stem (3) and a base (2), the base (2) comprising a bone support surface (4) on one side and on an opposite side a soft tissue load bearing surface (5). The stem extends from the base perpendicular to the bone support surface and is configured for insertion in a medullary canal (23) of an amputated bone (20), the bone support surface (4) being configured for abutment against a severed end (22) of said amputated bone. A diameter (d1) of the base is configured to be larger than an average diameter of a shaft (21) of said severed bone, the soft tissue load bearing surface (5) comprising a generally planar or slightly curved central portion (10) and a convexly curved radially outward portion (11) with a curvature greater than the central portion, the central portion (10) being oriented at an angle of between 4° to 8° to the bone support surface.Type: GrantFiled: January 28, 2014Date of Patent: August 8, 2017Assignee: LES HOPITAUX UNIVERSITAIRES DE GENEVEInventor: Alain Lacraz
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Patent number: 9657064Abstract: The present invention relates to a short cell penetrating peptide derived from the Epstein-Barr virus basic leucine zipper transcriptional activator (ZEBRA), optionally linked to a cargo molecule. It also relates to a complex comprising the cell penetrating peptide and a cargo molecule, as well as cells loaded with the complex and the use thereof in therapy and diagnosis.Type: GrantFiled: September 12, 2013Date of Patent: May 23, 2017Assignees: LES HOPITAUX UNIVERSITAIRES DE GENEVE, UNIVERSITE DE GENEVEInventors: Madiha Derouazi, Paul Walker, Pierre-Yves Dietrich
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Patent number: 9511226Abstract: A device for electrical stimulation of neural and/or muscular tissue. The device includes a cochlear implant being equipped with a power source, a speech processor, a microphone adapted to deliver sound signals to said speech processor, a current stimulator, at least an array of electrodes attached to the stimulator, and at least a signal sensor other than the microphone. The device further includes a signal transformation unit, said signal sensors being adapted to capture relevant input information and to deliver a corresponding input signal to the transformation unit, the latter allowing to transform said input signal received from the signal sensors into a modulated electrical output signal adapted to be treated by the speech processor of the cochlear implant.Type: GrantFiled: January 24, 2014Date of Patent: December 6, 2016Assignees: LES HOPITAUX UNIVERSITAIRES DE GENÈVE, Université de GenéveInventors: Marco Pelizzone, Angélica Perez Fornos, Maurizio Ranieri, Samuel Cavuscens
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Publication number: 20160001075Abstract: A device for electrical stimulation of neural and/or muscular tissue. The device includes a cochlear implant being equipped with a power source, a speech processor, a microphone adapted to deliver sound signals to said speech processor, a current stimulator, at least an array of electrodes attached to the stimulator, and at least a signal sensor other than the microphone. The device further includes a signal transformation unit, said signal sensors being adapted to capture relevant input information and to deliver a corresponding input signal to the transformation unit, the latter allowing to transform said input signal received from the signal sensors into a modulated electrical output signal adapted to be treated by the speech processor of the cochlear implant.Type: ApplicationFiled: January 24, 2014Publication date: January 7, 2016Applicants: LES HÔPITAUX UNIVERSITAIRES DE GENÉVE, Université de GenéveInventors: Marco PELIZZONE, Angélica Perez FORNOS, Maurizio RANIERI, Samuel CAVUSCENS
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Publication number: 20150239938Abstract: The present invention relates to a short cell penetrating peptide derived from ZEBRA, optionally linked to a cargo molecule. It also relates to a complex comprising said cell penetrating peptide and a cargo molecule, as well as cells loaded with said complex and the use thereof in therapy and diagnosis.Type: ApplicationFiled: September 12, 2013Publication date: August 27, 2015Applicants: LES HOPITAUX UNIVERSITAIRES DE GENEVE, UNIVERSITE DE GENEVEInventors: Madiha Derouazi, Paul Walker, Pierre-Yves Dietrich
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Publication number: 20100004661Abstract: A medical device for ablating tissues within a heart chamber comprising a guiding member intended to be introduced in the oesophagus of the patient and an ablating member comprising an ablation electrode mounted at the distal end or tip of catheter. Both the head of the guiding member and the tip of the ablating member are magnetised and can enter into magnetic coupling when their distal ends are brought in close contact. Once the magnetic coupling is achieved, the tip of the ablating member is guided by moving the guiding member. The guiding member can include sensors enabling to monitor physiological parameters during the intervention.Type: ApplicationFiled: July 6, 2007Publication date: January 7, 2010Applicant: Les Hopitaux Universitaires De GeneveInventors: Vitali Verin, Jan Sandtner