Patents Assigned to Les Laboratoires Servier
  • Polysubstituted 1,1-pyridylaminocyclopropanamine compounds
    Patent number: 7388022
    Abstract: A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl or (C1-C6)-trihaloalkoxy group or an optionally substituted amino group, R7 represents a hydrogen atom, a (C1-C6)alkyl group or an arylalkyl group, its enatiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: June 17, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • ?d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7384932
    Abstract: A ?d-crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: June 10, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Stephane Horvath, Marie-Noelle Auguste, Gerard Damien
  • Use of agomelatine in obtaining medicaments intended for the treatment of smith-magenis syndrome
    Publication number: 20080132577
    Abstract: The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, in obtaining medicaments intended for the treatment of Smith-Magenis syndrome.
    Type: Application
    Filed: November 21, 2007
    Publication date: June 5, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Elisabeth Mocaer, Agnes Fabiano
  • Use of agomelatine in obtaining medicaments intended for the treatment of periventricular leukomalacia
    Publication number: 20080125493
    Abstract: The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, in obtaining medicaments intended for the treatment of periventricular leukomalacia.
    Type: Application
    Filed: November 19, 2007
    Publication date: May 29, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Michael Spedding, Elisabeth Mocaer
  • 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives
    Patent number: 7378419
    Abstract: The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: May 27, 2008
    Assignees: Les Laboratoires Servier, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Claude Monneret, Daniel Dauzonne, John Hickman, Alain Pierre, Laurence Kraus-Berthier, Bruno Pfeiffer, Pierre Benard
  • Heterocyclic Oxime Compounds, A Process For Their Preparation And Pharmaceutical Compositions Containing Them.
    Publication number: 20080113974
    Abstract: Compounds of formula (I): wherein: X represents an oxygen atom or a sulphur atom, R1, R2, R3 and R4 are as defined in the description, A represents an alkylene chain as defined in the description, and B represents an alkyl or alkenyl group substituted by a group or R7, or B represents a group or R7.
    Type: Application
    Filed: January 26, 2006
    Publication date: May 15, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Aurelie Hurtevent, Jean-Martial L' Helgoual' Ch, Pascal Carato, Nicolas Lebegue, Veronique Leclerc, Pascal Berthelot, Catherine Dacquet, Alain Ktorza, Daniel-Henri Caignard
  • ?-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7361650
    Abstract: A ?-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: April 22, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Stéphane Horvath, Marie-Noëlle Auguste, Gérard Damien
  • ?d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7361652
    Abstract: A ?d-Crystalline form of ivabradine hydrochloride of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: April 22, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Stéphane Horvath, Marie-Noëlle Auguste, Gérard Damien
  • ?d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7361651
    Abstract: A ?d-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: April 22, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Stéphane Horvath, Marie-Noëlle Auguste, Gérard Damien
  • ?-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7361649
    Abstract: A ?-Crystalline form of ivabradine of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: April 22, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Stéphane Horvath, Marie-Noëlle Auguste, Gérard Damien
  • Method for synthesizing esters of N-[(S)-1-carboxybutyl]-(S)-alanine and use thereof for synthesizing perindopril
    Patent number: 7361757
    Abstract: A process for the synthesis of compounds of formula (I): wherein R represents a linear or branched (C1-C6)alkyl group. Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: April 22, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Fabienne Breard, Claude Fugier
  • Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
    Patent number: 7361662
    Abstract: A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as kinase modulators.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: April 22, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Sylvain Rault, Jean-Charles Lancelot, Marina Kopp, Daniel-Henri Caignard, Bruno Pfeiffer, Pierre Renard
  • ?-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7358240
    Abstract: A ?-crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: April 15, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Stephane Horvath, Marie-Noelle Auguste, Gerard Damien
  • Tetracyclic compounds
    Publication number: 20080076765
    Abstract: Compounds of formula I, of trans relative configuration: wherein: X represents an oxygen atom or an NR2 group, Y represents a group selected from —CH2—, —(CH2)2— and —CH?CH—, R1 and R2, which may be the same or different, each represents a hydrogen atom or a group selected from alkyl, cycloalkyl and cycloalkylalkyl, in racemic form or in the form of optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof. Medicinal products containing the same which are useful in the treatment of disorders of the central nervous system that involve the dopaminergic system.
    Type: Application
    Filed: September 25, 2007
    Publication date: March 27, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Jean-Louis Peglion, Christophe Poitevin, Mark Millan, Mauricette Brocco
  • Polysubstituted 1,1-pyridyloxycyclopropanamine compounds
    Patent number: 7348344
    Abstract: A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom, or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl, (C1-C6)trihaloalkoxy or optionally substituted amino group, its enantiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: March 25, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • 3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same
    Patent number: 7339061
    Abstract: Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR? wherein R? represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: March 4, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Daniel Brion, Lucien Israel, Alain Le Ridant, Catherine Harpey, Cherif Rabhi, El Bachir Kaloun
  • Process For The Preparation Of Perindopril And Salts Thereof
    Publication number: 20080051584
    Abstract: The present invention relates to a process for the preparation of the ACE inhibitor (2S,3aS,7aS)-1-((2S)-2-(((1S)-1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indol-2-carboxylic acid and of pharmaceutically acceptable salts thereof as well as to intermediates useful in said process.
    Type: Application
    Filed: May 10, 2005
    Publication date: February 28, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Marjo Merslavic, Janja Smid, Zdenka Tomsic
  • Process for the preparation of high purity perindopril and intermediates useful in the synthesis
    Patent number: 7326794
    Abstract: The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I? thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I—perindopril—is a known ACE inhibitor.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: February 5, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Guyla Simig, Tibor Mezei, Marta Porcs-Makkay, Attila Mandi
  • Process for the synthesis and crystalline form of agomelatine
    Publication number: 20080004352
    Abstract: A process for the industrial synthesis and new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Application
    Filed: May 31, 2007
    Publication date: January 3, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Jean-Claude Souvie, Isaac Blanco, Gilles Thominot, Genevieve Chapuis, Stephane Horvath, Gerard Damien
  • Naphthalene compounds
    Publication number: 20080004348
    Abstract: A compound selected from those of formula (I): wherein: R1 represents a group R4 or NHR4, wherein R4 is as defined in the description; R2 represents a substituted linear or branched (C1-C6)alkyl group; R3 represents a hydrogen or halogen atom or a linear or branched (C1-C6)alkyl or linear or branched (C2-C6)alkenyl group. Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 3, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Matthieu Desroses, Jean-Albert Boutin, Valerie Audinot