Patents Assigned to Les Laboratories Servier
  • Patent number: 11299542
    Abstract: The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 12, 2022
    Assignees: Les Laboratories Servier, Institut National de Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifiaue (CNRS)
    Inventors: Julie Pannequin, Laure Boudier, Dominique Joubert, Frédéric Hollande
  • Patent number: 10533050
    Abstract: The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin therapy for liver cancer, and compositions useful therefore.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: January 14, 2020
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Les Laboratories Servier
    Inventors: Leïla Houhou, Anne-Sophie Dumé, Dominique Joubert, Frédéric Hollande
  • Patent number: 8952179
    Abstract: Industrial synthesis process for the compound of formula (I):
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: February 10, 2015
    Assignee: Les Laboratories Servier
    Inventors: Nicolas Robert, Jean-Michel Lerestif, Jean-Pierre Lecouve, Marina Gaillard, Loic Meunier, Philippe Letellier, Mathieu Boiret
  • Patent number: 8927758
    Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: January 6, 2015
    Assignee: Les Laboratories Servier
    Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Daniel Dron, Eric Gojon, Maryse Phan
  • Patent number: 8900588
    Abstract: The present disclosure is directed to methods of treating and preventing breast cancer or recurrence of breast cancer with compositions comprising anti-progastrin antibodies.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: December 2, 2014
    Assignees: Les Laboratories Servier, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean-François Floch, Leïla Houhou, Françoise Cailler, Dominique Joubert, Frédéric Hollande
  • Patent number: 8900817
    Abstract: Progastrin levels are determined to diagnose one or more liver pathologies.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: December 2, 2014
    Assignee: Les Laboratories Servier
    Inventors: Jean-François Floch, Leïla Houhou
  • Patent number: 8871975
    Abstract: Process for the industrial synthesis of the compound of formula (I)
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: October 28, 2014
    Assignee: Les Laboratories Servier
    Inventors: Samir Zard, Béatrice Sire, Mehdi Boumediene
  • Patent number: 8778930
    Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: July 15, 2014
    Assignee: Les Laboratories Servier
    Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Daniel Dron, Eric Gojon, Maryse Phan
  • Patent number: 8663660
    Abstract: Polymerized micelles comprising polymerized amphiphilic molecules obtained starting from amphiphilic molecules having one or two lipid chains each comprising one or two polymerizable moieties and linked to a polar head.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: March 4, 2014
    Assignees: Les Laboratories Servier, Commissariat a l'Energie Atomique
    Inventors: Julien Ogier, Eric Doris, François Lefoulon, Thomas Arnauld
  • Patent number: 8614251
    Abstract: The invention provides a new crystalline form of agomelatine, preparation and use thereof. The X-ray powder diffraction diagram of the agomelatine crystalline form shows main peaks at the diffraction angles 2? 11.13°, 11.82°, 17.49°, 18.29°, 19.48°, 19.72°, 20.50°, 21.76°, 22.54°, 22.97°, 24.56°, 25.36°, 27.16° and 31.93°. Said new crystalline form is characterized by high purity, stability and good reproducibility, and thus is advantageous for the pharmaceutical formulation. In addition, the stability and solubility of said crystalline form are also superior over the several existing crystalline forms.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: December 24, 2013
    Assignee: Les Laboratories Servier
    Inventors: Hanbin Shan, Peng Zhang, Zhedong Yuan, Xudong Jiang, Yu Huang, Hubo Wang, Xufeng Cao, Xingdong Cheng, Xiong Yu
  • Patent number: 8524949
    Abstract: The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: September 3, 2013
    Assignee: Les Laboratories Servier
    Inventors: Hanbin Shan, Peng Zhang, Zhedong Yuan, Xudong Jiang, Yu Huang, Hubo Wang, Xufeng Cao, Xingdong Cheng, Hongjuan Pan, Xiong Yu
  • Patent number: 8236790
    Abstract: Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: August 7, 2012
    Assignee: Les Laboratories Servier
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Patent number: 8003682
    Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 represents a linear or branched (C1-C6)alkyl group, and n represents from 1 to 6. Medicaments.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: August 23, 2011
    Assignee: Les Laboratories Servier
    Inventors: Pascal Marchand, Vincent Babonneau, Sylvie Piessard, Muriel Duflos, Jean Albert Boutin, Valérie Audinot, Philippe Delagrange, Daniel-Henri Caignard
  • Patent number: 7999129
    Abstract: A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: August 16, 2011
    Assignee: Les Laboratories Servier
    Inventors: Jean-Claude Souvie, Isaac Gonzalez Blanco
  • Patent number: 7947743
    Abstract: The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, on its own or in association, in obtaining medicaments intended for the treatment of bipolar disorders, especially bipolar disorders of types I and II, and more especially bipolar disorders of type I.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: May 24, 2011
    Assignee: Les Laboratories Servier
    Inventors: Christian De Bodinat, Elisabeth Mocaer
  • Patent number: 7927813
    Abstract: The invention relates to a method of screening and identifying modulators of the protein interaction between new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: April 19, 2011
    Assignees: Les Laboratories Servier, Hybrigenics
    Inventors: Olivier Geneste, John Hickman, Jean-Christophe Rain
  • Patent number: 7867996
    Abstract: A ?-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: January 11, 2011
    Assignee: Les Laboratories Servier
    Inventors: Stephane Horvath, Marie-Noelle Auguste, Gerard Damien
  • Patent number: 7534896
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: May 19, 2009
    Assignee: Les Laboratories Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 7498330
    Abstract: Compound of formula (I): wherein: represents 1-oxidopyridyl substituted by the remainder of the molecule in any one of the positions 2, 3 and 4, m and n, which may be identical or different, each represent an integer of from 1 to 3, R1 represents hydrogen or alkyl, R2 and R3, which may be identical or different, each represent an atom or group selected from hydrogen, halogen, alkyl, hydroxy, acyloxy and alkoxy, or, together with the carbon atom carrying them, form a cycloalkane having from 3 to 6 carbon atoms, R4 and R5 each represent hydrogen, or are adjacent and, together with the carbon atoms carrying them, form a benzo ring, Ar represents aryl or heteroaryl. Medicinal products containing the same which are useful as thrombin inhibitors.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: March 3, 2009
    Assignee: Les Laboratories Servier
    Inventors: Guillaume De Nanteuil, Philippe Gloanec, Jean-Gilles Parmentier, Alain Benoist, Alain Rupin, Marie-Odile Vallez, Tony Verbeuren
  • Patent number: 7470806
    Abstract: A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: December 30, 2008
    Assignee: Les Laboratories Servier
    Inventors: Jean-Claude Souvie, Isaac Gonzalez Blanco