Abstract: Methods for preferentially delivering an active agent intracellularly to a reservoir cell that is infected with or susceptible to infection with an infectious agent, such as HIV. The active agent is part of a lipid-active agent complex that has a targeting ligand, such as a CTL/CTLD receptor-specific anchor, on its outer surface. Targeting systems are also disclosed. Such targeting systems are comprised of lipid-active agent complexes that contain targeting ligands, such as fucose and polyfucose derivatives, on their outer surfaces. The active agents include plant lectins, such as Con-A and MHL, and other drugs. Such methods and targeting systems may be used in the treatment of HIV and other infectious and non-infectious diseases.
Type:
Application
Filed:
March 21, 2005
Publication date:
December 20, 2007
Applicant:
LET THERE BE HOPE MEDICAL RESEARCH INSTITUTE
Inventors:
Robert Gieseler, Guido Marquitan, Michael Scolaro, Andreas Schwarz