Abstract: La present invention pertains to a composition of plasma-derived virally-safe factor VIII, obtained after nanometric filtration, said composition comprising von Willebrand factor (vWF) at a rate of 15% or less of decamers and higher multimers. Such compositions have a reduction factor of the virus titre higher than 4 log and are thus suitable for treatment of hemophilia.
Type:
Grant
Filed:
October 25, 2004
Date of Patent:
April 26, 2011
Assignee:
LFB SA
Inventors:
Abdessatar Chtourou, Michel Nogre, Roland Schmitthaeusler