Abstract: A device and method for a multiuser detection in a DS-CDMA system largely reduces an amount of data computation while reducing noise due to MAI. The method for a multiuser detection in a DS-CDMA system includes the steps of receiving a band-spread signal by a plurality of spreading codes respectively transmitted by each of multiusers, obtaining a plurality of sampled outputs from each of multiuser's messages by despreading the received signal with a matched filter, obtaining an MAI signal included in the plurality of sampled outputs by applying a minus (−) value of a cross-correlation value between the multiuser's spreading codes to the plurality of sampled outputs, removing the MAI signal from the sampled outputs by subtracting the MAI signal from the sampled outputs, and generating a binary data by comparing the sampled outputs from which the MAI signal is to be removed with a threshold value to recover the multiuser's messages.