Abstract: Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.
Type:
Application
Filed:
July 18, 2003
Publication date:
September 11, 2008
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, LG LIFE SCIENCES
Abstract: The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
Type:
Application
Filed:
September 22, 2003
Publication date:
May 25, 2006
Applicant:
LG Life Sciences
Inventors:
Jong-Ryoo Choi, Jae-Taeg Hwang, Dong-Gyu Cho, Kee-Yoon Roh, Chung-Hyung Kim, Chung-Mi Kim, Min-Joon Han, Jeong-Min Kim, Woo-Young Cho, Gyoung-Won Kim, Sin-Byoung Ahn
Abstract: The present invention relates to pyridine sulfonyl urea derivatives, salts or stereochemical isomers thereof showing an effective herbicidal activity in pre- and/or post-emergence treatment in rice farming, or to a method to use thereof, a method for the preparation thereof, an intermediate used for the preparation thereof, and a herbicidal composition comprising same.
Type:
Grant
Filed:
January 8, 2003
Date of Patent:
October 19, 2004
Assignee:
LG Life Sciences
Inventors:
Suk-Jin Koo, Jin-Ho Cho, Jeong-Su Kim, Seung-Hun Kang, Kyung-Goo Kang, Dae-Whang Kim, Hae-Sung Chang, Young-Kwan Ko, Jae-Wook Ryoo
Abstract: The present invention relates to pyridine sulfonyl urea derivatives, salts or stereochemical isomers thereof showing an effective herbicidal activity in pre- and/or post-emergence treatment in rice farming, or to a method to use thereof, a method for the preparation thereof, an intemediate used for the preparation thereof, and a herbicidal composition comprising same.
Type:
Grant
Filed:
December 5, 2003
Date of Patent:
July 13, 2004
Assignee:
LG Life Sciences
Inventors:
Suk-Jin Koo, Jin-Ho Cho, Jeong-Su Kim, Seung-Hun Kang, Kyung-Goo Kang, Dae-Whang Kim, Hae-Sung Chang, Young-Kwan Ko, Jae-Wook Ryu
Abstract: The present invention relates to pyridine sulfonyl urea derivatives, salts or stereochemical isomers thereof showing an effective herbicidal activity in pre- and/or post-emergence treatment in rice farming, or to a method to use thereof, a method for the preparation thereof, an intemediate used for the preparation thereof, and a herbicidal composition comprising same.
Type:
Application
Filed:
December 5, 2003
Publication date:
June 17, 2004
Applicant:
LG Life Sciences
Inventors:
Suk-Jin Koo, Jin-Ho Cho, Jeong-Su Kim, Seung-Hun Kang, Kyung-Goo Kang, Dae-Whang Kim, Hae-Sung Chang, Young-Kwan Ko, Jae-Wook Ryu