Abstract: The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for the thrombin inhibitor may be obtained in a high yield.
Type:
Grant
Filed:
March 15, 2002
Date of Patent:
March 21, 2006
Assignee:
LG Life Sciences Ltd.
Inventors:
Suk Kyoon Yoon, Bong Chan Kim, Won Hyuk Jung, Jae Chul Lee, Koo Lee, Cheol Won Park
Abstract: The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1), which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin, Levofloxacin, Gemifloxacin, Trovafloxacin, etc. The quinoline antibiotics obtained from the above compound of formula (1) show potent antibacterial activity, and so are advantageously used as a therapeutic agent for bacterial infections of humans or animals.
Abstract: The present invention relates to a process for preparing acid salts of Gemifloxacin, a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of process, improvement of productivity and improvement of yield, and the like by reducing conventional three-step process to two-step process.
Abstract: The present invention relates to water-insoluble, crosslinked amide derivatives of hyaluronic acid and manufacturing method thereof, where the amide derivatives of hyaluronic acid are characterized by crosslinking, of polymer or oligomer having two or more amine groups, with hyaluronic acid or its hyaluronate salts through amidation reaction. The water-insoluble, crosslinked amide derivatives of hyaluronic acid according to the present invention may be diversely used for prevention of adhesion after surgical operation, correction of facial wrinkles, dermal augmentation, tissue engineering, osteoarthritic viscosupplement etc.
Type:
Grant
Filed:
October 10, 2001
Date of Patent:
June 7, 2005
Assignee:
LG Life Sciences Ltd.
Inventors:
Tae-seok Moon, Jae-young Lee, Jin-hoon Kim, Kyu-beom Han
Abstract: The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are useful as anticoagulants.
Type:
Grant
Filed:
November 1, 2002
Date of Patent:
March 8, 2005
Assignee:
LG Life Sciences, Ltd.
Inventors:
Koo Lee, Won Hyuk Jung, Cheol Won Park, Sang Koo Lee, Sun Hwa Lee, Hee Dong Park
Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
Type:
Application
Filed:
April 15, 2004
Publication date:
October 7, 2004
Applicant:
LG Life Sciences, Ltd.
Inventors:
Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
Abstract: The present invention relates to novel thrombin inhibitors that are useful as anticoagulants. More particularly, the present invention is directed to peptide derivatives having high antithrombotic activity and high oral bioavailability.
Type:
Grant
Filed:
March 19, 2001
Date of Patent:
August 10, 2004
Assignee:
LG Life Sciences Ltd.
Inventors:
Koo Lee, Cheol-Won Park, Won-Hyuk Jung, Sang-Koo Lee
Abstract: The present invention relates to a fungicidal composition which comprises N-(&agr;-cycno-2-thenyl)-4-ethyl-2-(ethylamino)-5-thiazolecarboxamide (ethaboxam) and as an adjuvant polyoxyalkylene alkyl ether.
Abstract: The present invention provides a method of predicting a food-drug interaction in vivo, in the case of an orally administered drug interactive with digestive enzymes in the gastrointestinal tract, by measuring the activity of the drug to the digestive enzymes in vitro, which is based on the fact that the ingestion of foods causes the absorption of drug in vivo to decrease due to the above interaction between a drug and digestive enzymes. The present invention further provides methods of minimizing the change of absorption in vivo caused by the ingestion of foods by reducing the action of digestive enzymes, for example, introduction of prodrugs, modification of the chemical structure of drug, design of drug formulation, etc.
Type:
Application
Filed:
October 24, 2002
Publication date:
April 29, 2004
Applicant:
LG LIFE SCIENCES LTD.
Inventors:
Aeri Kim, Kwan Hyung Cho, Sun Hwa Lee, Suk Kyoon Yoon, Hee Dong Park, Kyung Ha Chung, Ho Jun Kim, Han Joo Maeng, Tae Hun Kim, Bong Chan Kim, Sung Ji Kim
Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
Type:
Grant
Filed:
August 20, 2002
Date of Patent:
April 20, 2004
Assignee:
LG Life Sciences, Ltd.
Inventors:
Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
Abstract: A novel 3-hydroxychromen-4-one derivative, pharmaceutically acceptable salt, hydrate, solvate or isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase (“CDK”) is disclosed. Further, a process for preparing the compound and a composition for suppression or treatment of cancer and diseases induced by cell proliferation such as inflammation, angiostenosis, angiogenesis, etc. is disclosed comprising the compound as an active component together with pharmaceutically acceptable carriers.
Type:
Grant
Filed:
November 1, 2002
Date of Patent:
January 27, 2004
Assignee:
LG Life Sciences Ltd.
Inventors:
Chang-Yong Hong, Jin-Ho Lee, Tae-Sik Park, Jong-Hyun Kim, Sei-Hyun Choi, Sook-Kyung Yoon, Hyun-Ho Chung, Ho-Sun Son, Eunice Eun-Kyeong Kim, Seong-Gu Ro, Shin-Wu Jeong, Dong-Myung Kim
Abstract: The present invention relates to an indazole derivative, pharmaceutically acceptable salt, solvated product and isomer thereof substituted with 1,1-dioxoisothiazolidine which are useful as inhibitors for Cyclin Dependent Kinase(CDK). The present invention also relates to an agent for inhibiting and treating diseases involving cell proliferation, e.g., cancer, inflammation, restenosis, angiogenesis, etc. which comprises the compound of formula (1) as an active ingredient together with a pharmaceutically acceptable carrier.
Abstract: The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.
Type:
Grant
Filed:
October 11, 2001
Date of Patent:
January 28, 2003
Assignee:
LG Life Sciences, Ltd.
Inventors:
Jong-Sung Koh, Hyun-Il Lee, You-Seung Shin, Hak-Joong Kim, Jin-Ho Lee, Jong-Hyun Kim, Hyun-Ho Chung, Shin-Wu Jeong, Tae-Saeng Choi, Jung-Kwon Yoo, Chung-Mi Kim, Kwi-Hwa Kim, Sun-Hwa Lee, Sang-Kyun Lee
Abstract: The present invention relates to a compound having formula I:
and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are useful as anticoagulants.
Type:
Grant
Filed:
December 29, 1999
Date of Patent:
December 10, 2002
Assignee:
LG Life Sciences, Ltd.
Inventors:
Koo Lee, Won Hyuk Jung, Cheol Won Park, Sang Koo Lee, Sun Hwa Lee, Hee Dong Park