Patents Assigned to Libragen
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Patent number: 9907760Abstract: The present invention relates to a cosmetic or pharmaceutical composition comprising N-acetylglucosamine-6-phosphate or a salt thereof and, optionally, a compound of the vitamin A family, and also to a device containing same.Type: GrantFiled: April 1, 2011Date of Patent: March 6, 2018Assignee: LIBRAGENInventors: Daniel Auriol, Fabrice Lefevre, Renaud Nalin, Gerard Redziniak
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Patent number: 9828407Abstract: The invention relates to the preparation of phenolic derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolic derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-?-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, anti-ischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.Type: GrantFiled: November 20, 2013Date of Patent: November 28, 2017Assignee: LIBRAGENInventors: Daniel Auriol, Renaud Nalin, Patrick Robe, Fabrice Lefevre
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Publication number: 20130012475Abstract: The present invention relates to a cosmetic or pharmaceutical composition comprising N-acetylglucosamine-6-phosphate or a salt thereof and, optionally, a compound of the vitamin A family, and also to a device containing same.Type: ApplicationFiled: April 1, 2011Publication date: January 10, 2013Applicant: LIBRAGENInventors: Daniel Auriol, Fabrice Lefevre, Renaud Nalin, Gerard Redziniak
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Publication number: 20110256115Abstract: The invention relates to [6)O-?-D-Glcp-(1?]n-6-O-?-D-Glcp-(1?-phenolic derivatives. These [6)O-?-D-Glcp-(1?]n-6-O-?-D-Glcp-(1?-phenolic derivatives of selected phenolics are new, have a solubility in water higher than that of their parent O-?-D-Glcp-(1?-phenolic derivatives and have useful applications in cosmetic, nutrition and pharmaceutical compositions, such as treating or preventing oxidative stress, a cancer, a cardiovascular disease, a bacterial infection, a viral infection, a fungal infection, a UV-induced erythema, an allergy, a metabolism disorder, diabetes, an obesity, a hormonal disorder, a bone disease, a pain, a brain disease, a mouth or teeth disease, an inflammatory or immune disorder.Type: ApplicationFiled: December 22, 2009Publication date: October 20, 2011Applicant: LibragenInventors: Daniel Auriol, Aurélien Ginolhac, Fabrice Lefevre, Renaud Nalin
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Publication number: 20110183930Abstract: The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-?-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.Type: ApplicationFiled: March 21, 2011Publication date: July 28, 2011Applicant: LIBRAGENInventors: DANIEL AURIOL, Renaud Nalin, Patrick Robe, Fabrice Lefevre
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Patent number: 7910522Abstract: The present invention relates to methods for the identification or cloning of polynucleotides encoding a selected phenotype, particularly from environmental DNA. In a specific embodiment, the method comprises (i) cloning environmental DNA fragments into E. coli cloning vectors to produce a metagenomic library, (ii) identifying or selecting cloning vectors in the library which contain DNA fragments having a particular characteristic of interest, (iii) modifying the identified or selected cloning vectors into shuttle or expression vectors for transfer and integration in a selected host cell, (iv) transferring the modified cloning vectors into the selected host-cell and (v) identifying or cloning the DNA fragments contained in the modified cloning vectors which encode the selected phenotype in the selected host cell.Type: GrantFiled: July 17, 2003Date of Patent: March 22, 2011Assignee: LibragenInventors: Renaud Nalin, Petar Pujic, Karine Tuphile, Benjamin Gillet
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Publication number: 20100323390Abstract: The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterisation of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.Type: ApplicationFiled: August 31, 2010Publication date: December 23, 2010Applicant: LIBRAGENInventors: Pierre Monsan, Claude Bensoussan, Philippe Reulet, Renaud Nalin, Patrick Robe, Karine Tuphile, Benjamin Gillet, Pierre Pujic
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Patent number: 7846874Abstract: The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterization of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.Type: GrantFiled: March 22, 2005Date of Patent: December 7, 2010Assignee: LibragenInventors: Pierre Monsan, Claude Bensoussan, Philippe Reulet, Renaud Nalin, Patrick Robe, Karine Tuphile, Benjamin Gillet, Pierre Pujic
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Publication number: 20090233876Abstract: The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-?-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application.Type: ApplicationFiled: June 13, 2007Publication date: September 17, 2009Applicant: LibragenInventors: Daniel Auriol, Renaud Nalin, Patrick Robe, Fabrice Lefevre
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Patent number: 6989249Abstract: A method for the indirect extraction of DNA greater than 300 kb in size from non-cultivatable organisms contained in an environmental sample is disclosed. The method comprises isolating the organisms from the sample and embedding the isolated organisms in a block of agarose where the organisms are subsequently lysed and the DNA subjected to a first alternating field electrophoresis to extract DNA fragments which are large in size and separate them from the cell debris. The first electrophoretic migration is followed by an enzymatic restriction step and additional electrophoretic migrations. The invention also encompasses DNA obtained by the method.Type: GrantFiled: October 28, 2002Date of Patent: January 24, 2006Assignee: LibragenInventors: Renaud Nalin, Patrick Robe, Van Tran Van