Abstract: Disclosed herein are cell lines transformed to express G-Protein Coupled Receptor GPCR22 and uses thereof for identifying guanosine analogues and/or other ligands to the receptor. In particular, techniques for transforming Drosophila Schneider 2 cells and human astrocytoma 1321N1 cell to express GPCR22 are disclosed as well as transformed cells lines. The transformed cell lines of the instant disclosure may be useful in identifying guanosine analogues and functional equivalents thereof.
Type:
Grant
Filed:
June 15, 2018
Date of Patent:
December 31, 2019
Assignee:
LIBRAMEN NATURALS INC.
Inventors:
Michel P. Rathbone, Shucui Jiang, Francesco Caciagli, Renata Ciccarelli, Patrizia Ballerini, Patrizia Di Iorio, Patricia Giuliani, Iolanda D'Alimonte
Abstract: Disclosed herein are cell lines transformed to express G-Protein Coupled Receptor GPCR22 and uses thereof for identifying guanosine analogues and/or other ligands to the receptor. In particular, techniques for transforming Drosophila Schneider 2 cells and human astrocytoma 1321N1 cell to express GPCR22 are disclosed as well as transformed cells lines. The transformed cell lines of the instant disclosure may be useful in identifying guanosine analogues and functional equivalents thereof.
Type:
Application
Filed:
June 15, 2018
Publication date:
November 22, 2018
Applicant:
LIBRAMEN NATURALS INC.
Inventors:
Michel P. RATHBONE, Shucui JIANG, Francesco CACIAGLI, Renata CICCARELLI, Patrizia BALLERINI, Patrizia DI IORIO, Patricia GIULIANI, Iolanda D'ALIMONTE
Abstract: Disclosed herein are cell lines transformed to express G-Protein Coupled Receptor GPCR22 and uses thereof for identifying guanosine analogs and/or other ligands to the receptor. In particular, techniques for transforming Drosophila Schneider 2 cells and human astrocytoma 1321N1 cell to express GPCR22 are disclosed as well as transformed cells lines. The transformed cell lines of the instant disclosure may be useful in identifying guanosine analogs and functional equivalents thereof.
Type:
Grant
Filed:
October 21, 2016
Date of Patent:
July 3, 2018
Assignee:
LIBRAMEN NATURALS INC.
Inventors:
Michel P. Rathbone, Shucui Jiang, Francesco Caciagli, Renata Ciccarelli, Patrizia Ballerini, Patrizia Di Iorio, Patricia Giuliani, Iolanda D'Alimonte
Abstract: Disclosed herein are cell lines transformed to express G-Protein Coupled Receptor GPCR22 and uses thereof for identifying guanosine analogues and/or other ligands to the receptor. In particular, techniques for transforming Drosophila Schneider 2 cells and human astrocytoma 1321N1 cell to express GPCR22 are disclosed as well as transformed cells lines. The transformed cell lines of the instant disclosure may be useful in identifying guanosine analogues and functional equivalents thereof.
Type:
Application
Filed:
October 21, 2016
Publication date:
April 27, 2017
Applicant:
LIBRAMEN NATURALS INC.
Inventors:
Michel P. RATHBONE, Shucui JIANG, Francesco CACIAGLI, Renata CICCARELLI, Patrizia BALLERINI, Patrizia DI IORIO, Patricia GIULIANI, Iolanda D'ALIMONTE