Patents Assigned to Lica Pharmaceuticals A/S
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Patent number: 7642367Abstract: The invention provides novel diamino-functionalized chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.Type: GrantFiled: May 19, 2003Date of Patent: January 5, 2010Assignee: Lica Pharmaceuticals A/SInventors: Simon Feldbæk Nielsen, Kristian Schønning, Hasse Kromann, Thomas Boesen, Mogens Larsen
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Patent number: 7423181Abstract: The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.Type: GrantFiled: May 19, 2003Date of Patent: September 9, 2008Assignee: Lica Pharmaceuticals A/SInventors: Simon Feldbæk Nielsen, Thomas Boesen, Mogens Larsen, Mette Bjerg Nielsen, Hasse Kromann
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Publication number: 20080027075Abstract: The present invention provides novel quaternary amino-functional chalcone derivatives and analogues exhibiting interesting antibacterial activity. The compounds have the general formula (Y1)m—Ar1(X1)—C(=O)VAr2(X2)?(Y2)p (I), wherein V designates —CH2—CH2—, —CH?CH— or —C?C—; Ar1 and Ar2 independently are aryl and heteroaryl; m=0, 1, 2, p=0, 1, 2, m+p>0; each Y1 and Y2 independently is -Z—N+(R1)(R2)R4 Q? (A); —NR3-Z—N+(R1)(R2)R4 Q? (B), or —O-Z—N+(R1)(R2)R4 Q? (C), R1, R2, R3, R4, X1, X2 are substituents, and Q? is an anion. The present invention also relates to the compounds for use as pharmaceutically active agents, in particular against bacterial infections (such as Gram-negative and Gram-positive bacteria, including antibiotic-sensitive or resistant strains), and in the medical treatment of bacterial infections in mammals.Type: ApplicationFiled: October 28, 2004Publication date: January 31, 2008Applicant: Lica Pharmaceuticals A/SInventor: Simon Feldbaek Nielsen
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Publication number: 20050227990Abstract: The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.Type: ApplicationFiled: May 19, 2003Publication date: October 13, 2005Applicant: Lica Pharmaceuticals A/SInventors: Simon Nielsen, Thomas Boesen, Mogens Larsen, Mette Bjerg Nielsen, Hasse Kromann
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Patent number: 6603046Abstract: The invention is drawn to novel bis-aromatic a,&bgr;-unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria.Type: GrantFiled: May 27, 1998Date of Patent: August 5, 2003Assignee: Lica Pharmaceuticals A/SInventors: Arsalan Kharazmi, Søren Brøgger Christensen, Chen Ming, Thor Grundtvig Theander